Monitoring and Characterization of Coronary Flow By Transthoracic Parametric Doppler (TPD) During Exercise Stress Test

This study has been terminated.
Information provided by (Responsible Party):
Echosense Ltd. Identifier:
First received: March 16, 2010
Last updated: August 2, 2014
Last verified: May 2011
The study is an open prospective study of coronary flow preferably of the left anterior descending artery (LAD), by a Transthoracic Parametric Doppler (TPD) system during conventional exercise stress test. The system is a noninvasive non-imaging device designed to monitor coronary flow velocity and display the data continuously during exercise stress tests. The system enables continuous monitoring of coronary flow during resting, stress loading and recovery phases. The study intent is to improve the stress test predictive value for CAD.

Condition Intervention Phase
Coronary Artery Disease
Device: ultrasound Doppler monitoring
Phase 0

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Echosense Ltd.:

Primary Outcome Measures:
  • Monitor coronary artery flow during exercise stress test. [ Time Frame: 1-3 months following the stress test ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Improve CAD predictive power of stress testing [ Time Frame: 1-3 months following the stress test ] [ Designated as safety issue: No ]

Enrollment: 60
Study Start Date: April 2010
Study Completion Date: February 2014
Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Intervention Details:
    Device: ultrasound Doppler monitoring
    Ultrasound Doppler monitoring throughout the stress test

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Scheduled to exercise stress test

Inclusion Criteria:

  • Age 18 years or older
  • Planned for ergometry test
  • Signed informed consent

Exclusion Criteria:

  • Excluded for stress test on a treadmill
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01089777

Cardiovascular department, Carmel medical center
Haifa, Israel, 34362
Sponsors and Collaborators
Echosense Ltd.
  More Information

Responsible Party: Echosense Ltd. Identifier: NCT01089777     History of Changes
Other Study ID Numbers: DOP04 
Study First Received: March 16, 2010
Last Updated: August 2, 2014
Health Authority: Israel: Ministry of Health

Additional relevant MeSH terms:
Coronary Artery Disease
Coronary Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Cardiovascular Diseases
Heart Diseases
Vascular Diseases processed this record on May 26, 2016