Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Hydrogen Sulfide as Prognostic Factor (H2S-1)

This study has been completed.
Information provided by (Responsible Party):
Podbregar Matej, University Medical Centre Ljubljana Identifier:
First received: March 12, 2010
Last updated: December 3, 2014
Last verified: December 2014
Hydrogen sulfide (H2S), better known as a poisonous gas, has emerged as the third gaseous transmitter in mammals, next to nitric oxide (NO) and carbon monoxide (CO). Increased production and higher serum concentrations were shown in inflammatory diseases, septic shock and stroke. The investigators will test the hypothesis that higher serum H2S concentrations on admission to intensive care unit (ICU) are linked with higher mortality in patients with shock of any reason.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Hydrogen Sulfide as Prognostic Factor

Further study details as provided by University Medical Centre Ljubljana:

Primary Outcome Measures:
  • Prognostic value of H2S [ Time Frame: In hospital; ICU mortality 30days ]

    relationship between H2S and mortality of patients during intensive care treatment,

    comparison of H2S and lactate prognostic value

Secondary Outcome Measures:
  • Correlation of H2S with vasopressor requirements [ Time Frame: ICU treatmennt 30days ]
    relationship between H2S and dose of vasopressors (noradrenaline, epinephrine) used

Enrollment: 50
Study Start Date: January 2010
Study Completion Date: January 2014
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
critically ill
Critically ill patients admitted to ICU

  Show Detailed Description


Ages Eligible for Study:   18 Years to 95 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Critically ill patients how are admitted in shock or hemodynamicaly unstable ino intensive care

Inclusion Criteria:

  • shock ( systemic arterial pressure less then 120mmHg, elevated lactate > 2.5mmol/L)

Exclusion Criteria:

  • patients admitted due to intoxication with H2S
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01088490

University Medical Center
Ljubljana, Slovenia, 1000
Sponsors and Collaborators
University Medical Centre Ljubljana
Principal Investigator: Matej Podbregar, MD PhD University Medical Centre Ljubljana
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Podbregar Matej, Prof., University Medical Centre Ljubljana Identifier: NCT01088490     History of Changes
Other Study ID Numbers: H2S_1
Study First Received: March 12, 2010
Last Updated: December 3, 2014

Keywords provided by University Medical Centre Ljubljana:
Hydrogen sulfide
critically ill

Additional relevant MeSH terms:
Hydrogen Sulfide
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs processed this record on May 22, 2017