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Effect of Treatment With Insulin Sensitizer on Arterial Properties, Metabolic Parameters and Liver Function in Patients With Nonalcoholic Fatty Liver Disease

This study has been completed.
Information provided by:
Wolfson Medical Center Identifier:
First received: March 9, 2010
Last updated: NA
Last verified: March 2010
History: No changes posted


Background: Insulin resistance has an important role in the development of nonalcoholic fatty liver disease (NAFLD) and is involved in both pathological processes: hepatic steatosis and atherosclerosis. Therefore, treatment of NAFLD with insulin sensitizers is likely to have a favorable effect towards hepatic steatosis and cardiovascular outcomes.

Objectives: The present study investigated the effect of metformin on arterial properties, metabolic parameters and liver function in patients with NAFLD. Methods In randomized, placebo controlled study, 63 patients with NAFLD were assigned to one of two groups: Group 1 received daily metformin; Group 2 received placebo. Pulse wave velocity (PWV) and augmentation index (AI) were performed using SphygmoCor (version 7.1, AtCor Medical, Sydney, Australia) at baseline and at the end of 4-month treatment period.. Metabolic measures and serum adiponectin levels were determined.

Condition Intervention Phase
Nonalcoholic Fatty Liver Disease Drug: Metformin Phase 1 Phase 2

Study Type: Interventional

Resource links provided by NLM:

Further study details as provided by Wolfson Medical Center:

Arms Assigned Interventions
Experimental: Metformin, Adiponectine, Arterial Compliance Drug: Metformin


Ages Eligible for Study:   40 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • In a single-center study, 63 patients (32 males and 31 females) diagnosed with nonalcoholic fatty liver disease were recruited from the outpatient clinic and evaluated for the study.

Exclusion Criteria:

  • Patients with history of unstable angina, MI, CVA or major surgery within the six months preceding entrance to the study.
  • Patients with unbalanced endocrine disease or any disease that might affect absorption of medications.
  • Patients with plasma creatinine > 1.5 mg/dl, and electrolyte abnormalities.
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Please refer to this study by its identifier: NCT01084486

Wolfson Medical Center
Holon, Israel, 58100
Sponsors and Collaborators
Wolfson Medical Center
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT01084486     History of Changes
Other Study ID Numbers: WolfsonMC-2007-9
Study First Received: March 9, 2010
Last Updated: March 9, 2010

Keywords provided by Wolfson Medical Center:
nonalcoholic fatty liver disease
Pulse wave velocity
augmentation index

Additional relevant MeSH terms:
Liver Diseases
Fatty Liver
Non-alcoholic Fatty Liver Disease
Digestive System Diseases
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on September 19, 2017