This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Optimal End-Tidal (ET) Sevoflurane and Desflurane Concentration for Extubation of Supreme Laryngeal Mask Airway (LMA) in Adults

This study has been completed.
Malaysian Society of Anaesthesiologists
Information provided by (Responsible Party):
Cindy Thomas Joseph, University of Malaya Identifier:
First received: March 8, 2010
Last updated: December 2, 2015
Last verified: December 2015

The purpose of this study is to determine the optimal volatile anaesthetic (sevoflurane and desflurane) to remove a Supreme LMA in adults in which there is minimal airway response.

Null hypothesis: there is no significant difference between the optimal end tidal concentration of sevoflurane and desflurane for Supreme LMA removal.

Condition Intervention
Airway Complications Drug: Sevoflurane Drug: Desflurane

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Optimal End-Tidal Concentration of Sevoflurane and Desflurane for Removal of Supreme Laryngeal Mask Airway in Anaesthetized Adults

Resource links provided by NLM:

Further study details as provided by Cindy Thomas Joseph, University of Malaya:

Primary Outcome Measures:
  • Optimal end tidal concentration of sevoflurane/ desflurane [ Time Frame: 6 months ]

Secondary Outcome Measures:
  • presence of airway response [ Time Frame: 10 mins after surgery ]

Enrollment: 54
Study Start Date: November 2009
Study Completion Date: July 2010
Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Sevoflurane
1 arm will receive sevoflurane at varying concentrations at which extubation is attempted according to the Dixon up and down method
Drug: Sevoflurane
Comparing the optimal end-tidal concentration sevoflurane and desflurane for LMA extubation
Experimental: Desflurane
1 arm will receive desflurane at varying end tidal concentration at which extubation will be attempted according to Dixon up and down method
Drug: Desflurane
Comparing the optimal end-tidal concentration sevoflurane and desflurane for LMA extubation

Detailed Description:

The manufactures' instructions for removal of the LMA recommend waiting until protective reflexes have returned. However, the appropriate timing for removal remains controversial. A more frequent incidence of airway hyperreactivity and complications has been reported by some studies when the LMA was removed in the awake state versus the anesthetized state. Techniques that reduce the time from LMA removal to the return of protective airway reflexes would minimize the risk of aspiration, contamination, or airway obstruction.

With increasingly common use of Supreme LMA in anaesthetic practice, a safe and suitable depth for removal of the Supreme LMA requires research.

Thus the determination of the optimal end-tidal concentration of commonly used volatile agents ie. Sevoflurane and Desflurane for Supreme LMA removal requires research, both for patient safety and minimising anaesthetic costs in dealing with airway complications.


Ages Eligible for Study:   18 Years to 49 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. ASA 1-2 patients
  2. Age 18 - 49 years old
  3. Elective surgery of short duration ( < 2 hours ) which require local anaesthetic infiltration

Exclusion Criteria:

  1. Upper respiratory tract symptoms in the previous 10 days
  2. Risk of gastric oesophageal reflux or regurgitation
  3. Known or predicted difficult airway
  4. Poor dentition with high risk of damage
  5. BMI > 30 kg/m2
  6. Refusing to participate
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01083953

University Malaya Medical Centre
Kuala Lumpur, Wilayah Persekutuan, Malaysia, 59100
Sponsors and Collaborators
University of Malaya
Malaysian Society of Anaesthesiologists
Principal Investigator: Cindy Thomas Joseph Department of Anaesthesiology, UMMC
  More Information

Responsible Party: Cindy Thomas Joseph, doctor, University of Malaya Identifier: NCT01083953     History of Changes
Other Study ID Numbers: supreme sevo vs des
Study First Received: March 8, 2010
Last Updated: December 2, 2015

Keywords provided by Cindy Thomas Joseph, University of Malaya:
end tidal concentration

Additional relevant MeSH terms:
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General
Central Nervous System Depressants
Physiological Effects of Drugs processed this record on September 19, 2017