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Rotational Narrow Strip Versus Full Conjunctival Graft in Pterygium Excision

This study has been completed.
Ministry of Health, Malaysia
Information provided by:
University of Malaya Identifier:
First received: March 8, 2010
Last updated: March 9, 2010
Last verified: March 2010
To compare the efficacy of rotational narrow strip conjunctival graft to full conjunctival graft in primary pterygium excision. Risk analysis of factors that may affects the recurrence rate.

Condition Intervention
Pterygium Procedure: Rotational Narrow Strip Conjunctival Graft Procedure: Full Conjunctival Graft

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Rotational Narrow Strip Versus Full Conjunctival Graft in Pterygium Excision

Further study details as provided by University of Malaya:

Primary Outcome Measures:
  • Recurrence Rate of Pterygium operated with Rotational Narrow Strip Conjunctival Graft and Full Conjunctival Graft Excision [ Time Frame: 1 year ]

Secondary Outcome Measures:
  • Analysis of risk factors associated with recurrence of pterygium [ Time Frame: 1 year ]

Enrollment: 94
Study Start Date: July 2007
Study Completion Date: July 2009
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Rotational Narrow Strip Graft
Technique of surgery
Procedure: Rotational Narrow Strip Conjunctival Graft
Surgical technique
Active Comparator: Full Graft
Surgical technique
Procedure: Full Conjunctival Graft
Surgical technique

Detailed Description:

Pterygium is a raised, wing-shaped growth of fibrovascular tissue that extends horizontally from the bulbar conjunctiva, crossing the limbus, and onto the cornea. It is a common ocular surface disease in Malaysia.

Pterygium can cause chronic ocular irritation, redness, tearing, visual impairment and poor cosmesis. Treatment of symptomatic pterygium remains surgical. Surgery should achieve low recurrence rate and acceptable cosmesis. Various surgical techniques had been described with variable success.

In this study, we compared the efficacy of Rotational Narrow Strip Conjunctival Graft with the conventional full conjunctival graft in pterygium excision. Patient will be follow up for a year after pterygium surgery. Outcome will be recurrence rate between the two groups at one year. Risk analysis of certain factors that affects the recurrence rate will be discussed.


Ages Eligible for Study:   21 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. Significant and symptomatic primary pterygium clinically requiring excision
  2. Willingness to participate in research project and to attend research time

Exclusion Criteria:

  1. Age < 21 years
  2. Glaucoma in the study eye
  3. Other concurrent ocular surface pathology
  4. Infection of the ocular surface
  5. Poor general health
  Contacts and Locations
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Please refer to this study by its identifier: NCT01083927

Sarawak General Hospital
Kuching, Sarawak, Malaysia, 93586
Sponsors and Collaborators
University of Malaya
Ministry of Health, Malaysia
Principal Investigator: Lo Sheau Kang, MBBS University Malaya Eye Research Centre
  More Information

Responsible Party: Dr Lo Sheau Kang, University Malaya Eye Research Center Identifier: NCT01083927     History of Changes
Other Study ID Numbers: UMERC003
Study First Received: March 8, 2010
Last Updated: March 9, 2010

Keywords provided by University of Malaya:

Additional relevant MeSH terms:
Conjunctival Diseases
Eye Diseases processed this record on September 19, 2017