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Resistant Arterial Hypertension Cohort Study (RAHyCo)

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2011 by Georg EHRET, University Hospital, Geneva
Information provided by (Responsible Party):
Georg EHRET, University Hospital, Geneva Identifier:
First received: March 8, 2010
Last updated: August 26, 2011
Last verified: August 2011
The purpose of this study is to investigate the epidemiology of resistant hypertension, evaluate the efficacy and feasibility of a standardized drug treatment regimen (including the randomization of two doses of the diuretic used - chlorthalidone), study two interventions in the group of patients that is non-compliant, and study environmental and genetic variables of individuals with resistant hypertension in a family design.

Condition Intervention Phase
Essential Hypertension
Resistant Hypertension
Drug: chlorthalidone
Behavioral: motivational intervention for non-compliant individuals
Drug: standardized anti-hypertensive treatment
Phase 4

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Interventional Prospective Cohort Study, Multi-center With Nested Case-control Studies (Family-based and Non-family Based) on Individuals With Resistant Arterial Hypertension.

Resource links provided by NLM:

Further study details as provided by Georg EHRET, University Hospital, Geneva:

Primary Outcome Measures:
  • blood pressure control [ Time Frame: at 12 weeks after initiation of standard treatment ]

Secondary Outcome Measures:
  • cardiovascular morbidity and mortality [ Time Frame: 5 years ]
    additional secondary: BP control at yearly follow-up

Biospecimen Retention:   Samples With DNA
serum, DNA, urine

Estimated Enrollment: 200
Study Start Date: April 2011
Estimated Study Completion Date: April 2018
Estimated Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
chlorthalidone Drug: chlorthalidone
chlorthalidone 25mg/d vs. chlorthalidone 50mg/d
motivational invervention
motivational interview(s) vs. repeated calls vs. no particular intervention
Behavioral: motivational intervention for non-compliant individuals
motivational interview(s) vs. repeated calls vs. no particular intervention
standardized anti-hypertensive treatment Drug: standardized anti-hypertensive treatment
olmesartan, amlodipine, chlorthalidone, +- spironolactone


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients addressed to a speciality consultation at Geneva University Hospital

Inclusion Criteria:

  • informed consent
  • resistant hypertension at the moment of inclusion
  • 18 years or more, both sexes are included
  • women at reproductive age: consenting to use oral contraception

Exclusion Criteria:

  • patients mentally impaired or unable to give informed consent
  • patients speaking only a foreign language other than French, German, or English
  • patients living far away, making the study visits not practical
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01083017

Contact: Georg B EHRET, MD 011-41-22-7920322

Geneva University Hospitals Recruiting
Geneva, Switzerland
Contact: Georg B EHRET, MD    011-41-22-3723311   
Contact: Antoinette PECHERE, MD    011-41-22-3723311      
Lausanne University Hospital, CHUV Not yet recruiting
Lausanne, Switzerland
Contact: Gregoire Wuerzner, MD         
Kantonsspital Luzern Recruiting
Luzern, Switzerland
Contact: Paul Erne, MD         
Sponsors and Collaborators
University Hospital, Geneva
Principal Investigator: Antoinette PECHERE, MD Geneva University Hospitals, Switzerland
Principal Investigator: Georg B EHRET, MD Geneva University Hospitals, Switzerland
  More Information

Responsible Party: Georg EHRET, intern, University Hospital, Geneva Identifier: NCT01083017     History of Changes
Other Study ID Numbers: RAHyCOstudy
33CM30‐124087 ( Other Grant/Funding Number: Swiss National Science Foundation )
CER09-237 ( Other Identifier: IRB )
Study First Received: March 8, 2010
Last Updated: August 26, 2011

Additional relevant MeSH terms:
Antihypertensive Agents
Vascular Diseases
Cardiovascular Diseases
Natriuretic Agents
Physiological Effects of Drugs
Sodium Chloride Symporter Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action processed this record on May 25, 2017