Autoimmune Phenomena After Acute Stroke (ARIMIS)
Recruitment status was: Active, not recruiting
The damage of the brain parenchyma, as well as the stroke-induced dysfunction of the blood-brain-barrier can make previously hidden CNS antigens "visible", and can thus lead to the development of autoimmune mechanisms.
It seems plausible that stroke-associated immunodepression influences the development and the phenotype of these autoreactive immune responses.
This study will investigate whether cerebral ischemia leads to changes in the immune response, in particular to the development and/or proliferation of autoreactive effector T-cells and/or regulatory T-cells. Furthermore, the association between the severity and the phenotype of this autoimmune response and the clinical course, i.e. prognosis and mortality, will be investigated.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Autoimmune Phenomena After Acute Stroke - the Role of Stroke-induced Immunodepression|
- autoantigen-specific T-cells in patients with acute media infarct [ Time Frame: within 36 h ] [ Designated as safety issue: No ]quantitative determination of autoantigen-specific T-cells in patients with acute media infarct
- leukocytes in patients with acute media infarct [ Time Frame: within 36 hours ] [ Designated as safety issue: No ]quantitative and qualitative analysis of leukocytes in patients with acute media infarct
- frequency and phenotype of CNS-autoreactive immune cells under the influence of immunodepression [ Time Frame: within 36 h, after day 3, 7, 90 and 180 ] [ Designated as safety issue: No ]
- clinical course, i.e. mortality and prognosis (measured by mod. Rankin Scale) [ Time Frame: after day 90 and 180 ] [ Designated as safety issue: No ]
- clinical course, i.e. mortality and prognosis (measured by Bartel Index) [ Time Frame: after day 90 and 180 ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||December 2009|
|Estimated Study Completion Date:||August 2013|
|Estimated Primary Completion Date:||August 2013 (Final data collection date for primary outcome measure)|
|patients with acute media infarct|
|controls with cardiovascular risks|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01082783
|Charite University Berlin|
|Berlin, Germany, 10117|
|Principal Investigator:||Andreas Meisel, MD||Charite University, Berlin, Germany|