Congestive Heart Failure: Causes of Sudden Worsening

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01081925
Recruitment Status : Unknown
Verified February 2010 by University Hospital Hradec Kralove.
Recruitment status was:  Recruiting
First Posted : March 5, 2010
Last Update Posted : March 5, 2010
Information provided by:
University Hospital Hradec Kralove

Brief Summary:
The purpose of the study is to recognize main causes of acute decompensation of chronic congestive heart failure.

Condition or disease
Congestive Heart Failure

Detailed Description:
Congestive heart failure (CHF) presents a very significant cause of morbidity and mortality. The prevalence of CHF is between 2 and 4% and rises with age (in 70- to 80-year-old people is between 10 and 20%). CHF is the cause of 5% of all acute hospital admissions and accounts for 2% of expenses on health. The most common causes of worsening of the chronic CHF are ischemia, arrhythmias, valvular dysfunction, systemic or pulmonary hypertension, volume overload or fluid retention, high output conditions (infection, anemia, thyrotoxicosis), drugs (NSAIDs, cyclo-oxygenase (COX) inhibitors, thiazolidinediones) and medication nonadherence. The goal of this study is to determine the proportion of various reasons of acute worsening of CHF, using commonly available methods including assessment of serum drug levels.

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Congestive Heart Failure: Causes of Sudden Worsening
Study Start Date : February 2010
Estimated Primary Completion Date : February 2012
Estimated Study Completion Date : February 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Failure
U.S. FDA Resources

Congestive heart failure
Patients suffering from sudden worsening of congestive heart failure

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients suffering from sudden worsening of congestive heart failure, who are examined at the Emergency department or admitted to University Hospital

Inclusion Criteria:

  • able to provide informed consent
  • aged 19 years or more
  • history of heart failure of at least one month
  • examined or hospitalized for acute dyspnea at rest or with minimal exertion
  • clinical signs of fluid overload defined as at least one of following:
  • rales
  • jugular venous distension
  • peripheral edema
  • pulmonary congestion on X-ray
  • NT-proBNP above 210 pmo/l

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01081925

Contact: Radek Pelouch, MD 00420495834740
Contact: Jiri Ceral, MD 00420495832652

Czech Republic
University Hospital Hradec Kralove Recruiting
Hradec Kralove, Czech Republic, 50005
Principal Investigator: Radek Pelouch         
Sub-Investigator: Jiri Ceral, MD         
Sub-Investigator: Miroslav Solar, MD         
Sponsors and Collaborators
University Hospital Hradec Kralove
Principal Investigator: Radek Pelouch, MD University Hospital Hradec Kralove

Responsible Party: Pelouch Radek, MD, University Hospital Hradec Kralove Identifier: NCT01081925     History of Changes
Other Study ID Numbers: MSM0021620817-HKJC
First Posted: March 5, 2010    Key Record Dates
Last Update Posted: March 5, 2010
Last Verified: February 2010

Keywords provided by University Hospital Hradec Kralove:
Congestive Heart Failure
Cardiac Failure

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases