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Vitamin D and Zinc Levels in Patients Undergoing Ergometry Test

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2010 by Assaf-Harofeh Medical Center.
Recruitment status was:  Active, not recruiting
Information provided by:
Assaf-Harofeh Medical Center Identifier:
First received: March 3, 2010
Last updated: April 6, 2010
Last verified: February 2010
Low vitamin D levels were found to be associated with cardiovascular morbidity and mortality. Low zinc levels are associated with an increased atherosclerotic burden. Therefore we hypothesized that patients with pathological stress test would have low levels of Vitamin D and zinc compared to patients with a normal stress test.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Vitamin D and Zinc Levels in Patients Undergoing Ergometry Test

Resource links provided by NLM:

Further study details as provided by Assaf-Harofeh Medical Center:

Primary Outcome Measures:
  • positive stress test [ Time Frame: one year ]

Biospecimen Retention:   Samples Without DNA
blood will be collected for vit d and zinc , stored until all samples are collected and only than the laboratoty will analyze it.

Estimated Enrollment: 200
Study Start Date: March 2010
Estimated Study Completion Date: March 2011
Estimated Primary Completion Date: March 2011 (Final data collection date for primary outcome measure)
positive ergometry
positive ergometry as specified by a cardiologist on site.
negative ergometry.
negative ergometry as specified by cardiologist on site.
patients with positive stress test
100 patients with positive ergometry test as specified by the cardiologist in charge. All patients are ambulatory patients referred for routine check up.

Detailed Description:

Hypovitaminosis D is generally defined as 25(OH)D levels of < 20ng/ml, while levels of 21-29ng/ml indicate insufficiency and those above 30ng/ml are regarded as sufficient.

The rational behind the observations associating vitamin D deficiency with CVD is that on the one hand, hypovitaminosis D was found to be associated with traditional risk factors such as hypertension (HTN),diabetes mellitus (dm),obesity, dyslipidemia and metabolic syndrome , on the other hand, experimental data demonstrated that vitamin D could affect cardiac muscle cells directly, control parathyroid (PTH) hormone secretion, regulate the rennin- angiotensin- aldosterone system and the immune system, all of which could influence cardiovascular risk.

Epidemiological studies further support this association, demonstrating high prevalence of hypovitaminosis D among U.S. adults with cardiovascular disease (74%). An association between low vitamin D levels and increased myocardial infarction risk as well as total mortality has been also observed.

Low 25hydroxyvitamin D[ 25(OH)D] levels were also independently associated with all cause and CVD mortality among patients scheduled for coronary catheterization.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
  • Over 18 years old
  • CCT > 60 ml/min
  • No IHD
  • No hyper/hypoparathyroidism
  • No active malignancy
  • Not taking calcium, phosphate

Inclusion Criteria:

  • Over 18 years old
  • CCT > 60 ml/min
  • No IHD
  • No hyper/hypoparathyroidism
  • No active malignancy
  • Not taking calcium, phosphate

Exclusion Criteria:

  • Under 18 years of age
  • Not fulfilling inclusion criteria
  Contacts and Locations
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Please refer to this study by its identifier: NCT01080274

Assaf Harofeh Mc
Zerifin, Israel
Sponsors and Collaborators
Assaf-Harofeh Medical Center
  More Information

Responsible Party: Renana Shor MD, Assaf-Harofeh Medical Center Identifier: NCT01080274     History of Changes
Other Study ID Numbers: 22/10
Study First Received: March 3, 2010
Last Updated: April 6, 2010

Keywords provided by Assaf-Harofeh Medical Center:
vitamin d

Additional relevant MeSH terms:
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Vitamin D
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents processed this record on May 25, 2017