Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients
COPD patients have a reduced exercise tolerance due to a ventilatory limitation.
Several studies have shown altered skeletal muscle function. The investigator will study the physiological response to knee-extensor exercise in COPD patients.
|Chronic Obstructive Pulmonary Disease||Behavioral: High intensity knee-extensor training|
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients|
- Peak power [ Time Frame: At inclusion and after 6 weeks of training ]
- Mitochondrial respiration, Vmax [ Time Frame: At inclusion and after 6 weeks of training ]
|Study Start Date:||February 2009|
|Study Completion Date:||December 2012|
|Primary Completion Date:||June 2010 (Final data collection date for primary outcome measure)|
Experimental: Knee extensor exercise training
High intensity aerobic knee-extensor exercise training
Behavioral: High intensity knee-extensor training
High intensity aerobic knee-extensor exercise training, 4x 3 minutes interval training at < 90 % of peak power, 3 days/week for 6 weeks
Reduced exercise tolerance is one of the hallmarks of COPD. The principal causes for exercise intolerance are ventilatory limitation leading to deconditioning and inactivity. However the weak correlation between exercise capacity and FEV1 implies that other factors than reduced pulmonary function contribute to this impairment as well. Several studies have found changes in skeletal muscle, with fibre shift, increased oxidative stress, increased inflammatory cytokines and impaired mitochondrial function, suggesting a lower limb dysfunction.
Numerous exercise studies in COPD patients have shown physiological and physiological benefits of training and endurance training is now regarded as an important part in pulmonary rehabilitation.
In this study we investigate training effects in patients with moderate to severe COPD with special focus on skeletal muscle.
COPD patients will perform high intensity aerobic interval knee-extensor exercise training 3 days/week for six weeks . At baseline and follow-up, muscle oxygen consumption and mitochondrial respiration will be measured.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01079221
|Study Director:||Ulrik Wisløff, PhD prof.||Norwegian University of Science and Technology|