Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia (CATCH)
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ClinicalTrials.gov Identifier: NCT01077752 |
Recruitment Status :
Completed
First Posted : March 1, 2010
Last Update Posted : January 22, 2014
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Pain, Postoperative | Drug: continuous ropivacaine preperitoneal infusion Drug: intravenous lidocaine infusion Drug: parenteral analgesia combining acetaminophen and morphine Drug: NaCl | Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 95 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Triple (Participant, Care Provider, Investigator) |
Primary Purpose: | Treatment |
Official Title: | Effect of Local Anesthetic Continuous Preperitoneal Wound Infiltration on Incisional Hyperalgesia Following Colorectal Laparoscopic Surgery |
Study Start Date : | February 2010 |
Actual Primary Completion Date : | June 2012 |
Actual Study Completion Date : | February 2013 |
Arm | Intervention/treatment |
---|---|
Experimental: 1
Patients with continuous ropivacaine preperitoneal infusion
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Drug: continuous ropivacaine preperitoneal infusion
Bolus of 20 mg after the surgery then 20 mg per hour during 48 hours Drug: parenteral analgesia combining acetaminophen and morphine parenteral analgesia combining acetaminophen and morphine |
Active Comparator: 2
Patients with intravenous lidocaine infusion
|
Drug: intravenous lidocaine infusion
Bolus of 60 mg after the surgery then 60 mg per hour during 48 hours Drug: parenteral analgesia combining acetaminophen and morphine parenteral analgesia combining acetaminophen and morphine |
Placebo Comparator: 3
Patients without local anesthetics
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Drug: parenteral analgesia combining acetaminophen and morphine
parenteral analgesia combining acetaminophen and morphine Drug: NaCl NaCl |
- Pericicatricial hyperalgesia area [ Time Frame: 72 hours after surgery ]
- Pain intensity (rest/mobilization and long-term) [ Time Frame: 72 hours, 3 months and 6 months after surgery ]
- Morphine consumption [ Time Frame: During 5 days after surgery ]

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Ages Eligible for Study: | 18 Years to 80 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Age 18 to 80
- ASA status 1 - 3
- Colorectal laparoscopic surgery with piece removal
- French speaking
- Written informed consent
Exclusion Criteria:
- laparoscopy without colorectal extraction
- chronic pain
- analgesic consumption during the 24 hours previous to the surgery
- morphine and LA intolerance
- drug addiction
- inflammatory bowel disease
- general inflammatory disease
- sepsis
- anemia < 10 gr/dl
- liver or renal or cardiac insufficiency
- uncontrolled diabetes
- preoperative consumption of opiate/corticosteroid/beta-blockers, and anti-arrhythmic drugs, MAOIs, neuroleptics.
- preoperative consumption of NSAIDs excluding aspirin referred cardiology

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01077752
France | |
Departement d'Anesthesie-Reanimation, Hopital Saint-Antoine | |
Paris, France, 75012 |
Principal Investigator: | Marc Beaussier, MD PhD | Assistance Publique - Hôpitaux de Paris |
Responsible Party: | Assistance Publique - Hôpitaux de Paris |
ClinicalTrials.gov Identifier: | NCT01077752 |
Other Study ID Numbers: |
AOR 08028 |
First Posted: | March 1, 2010 Key Record Dates |
Last Update Posted: | January 22, 2014 |
Last Verified: | January 2014 |
Pain, postoperative Local infiltration Hyperalgesia, postoperative |
Local anesthetic, ropivacaine, lidocaine Colorectal laparoscopic surgery Pain management after colorectal laparoscopic surgery |
Hyperalgesia Pain, Postoperative Postoperative Complications Pathologic Processes Pain Neurologic Manifestations Somatosensory Disorders Sensation Disorders Nervous System Diseases Acetaminophen Lidocaine Morphine Ropivacaine Anesthetics, Local Anesthetics |
Central Nervous System Depressants Physiological Effects of Drugs Sensory System Agents Peripheral Nervous System Agents Anti-Arrhythmia Agents Voltage-Gated Sodium Channel Blockers Sodium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Analgesics, Opioid Narcotics Analgesics Analgesics, Non-Narcotic Antipyretics |