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Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01076881
First Posted: February 26, 2010
Last Update Posted: February 26, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Universidade Católica de Pelotas
  Purpose

This is a randomized trial with participants recruited from one dialysis unit of a Brazilian university hospital. Hemodialysis patients were assigned to receive the resistance exercise combined with an aerobic training or the resistance training alone for a period of 10 weeks. The functional performance of patients was assessed before and after the intervention through the six-minute walk test (6MWT). The difference over time of the 6MWT was compared between the groups through multivariate linear regression.

Thirteen patients were allocated for each group of intervention. The difference in distance walked before and after intervention in the combined training group was of +39.7 (61.4) meters, and this difference in the resistance training group was of -19.2 (53.9) meters, p=0.01. In multivariate analysis with adjustment for age, skin color, gender, hematocrit, time since starting dialysis, Kt/V and baseline values of 6MWT, the type of training remained significantly associated with the amount of increase in walked distance.

Although the best protocol of exercise for patients on dialysis is not yet clear, in the investigators sample of hemodialysis patients the combination of aerobic and resistance training was more effective to improve functional performance.


Condition Intervention
End Stage Renal Disease Behavioral: exercise training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial

Resource links provided by NLM:


Further study details as provided by Universidade Católica de Pelotas:

Primary Outcome Measures:
  • physical performance [ Time Frame: 10 weeks ]

Secondary Outcome Measures:
  • dialysis adequacy (KtV) [ Time Frame: 4/8/10 weeks ]

Enrollment: 26
Study Start Date: December 2008
Study Completion Date: March 2009
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: combined aerobic and resistance training Behavioral: exercise training
Active Comparator: resistance training alone Behavioral: exercise training

  Eligibility

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • to be on hemodialysis therapy for longer than 3 months
  • to be already included in the resistance training protocol during dialysis
  • to receive erythropoietin for the treatment of anemia
  • hemoglobin level greater than 9.0 g/dL
  • to be able to maintain sitting and standing balance and ambulatory without assistance.

Exclusion Criteria:

  • symptomatic ischemic heart disease
  • recent myocardial infarction of less than 6 months
  • uncontrolled hypertension
  • pericardial or pleural friction rub
  • aortic stenosis
  • active musculoskeletal lower-extremity problem, or history of vertebral fracture caused by osteoporosis
  • patients were also excluded if they participated in formal organized exercise programs outside the dialysis unit.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01076881


Locations
Brazil
Hospital Universitário São Francisco de Paula
Pelotas, RS, Brazil
Sponsors and Collaborators
Universidade Católica de Pelotas
  More Information

ClinicalTrials.gov Identifier: NCT01076881     History of Changes
Other Study ID Numbers: UCPelotas01
First Submitted: February 17, 2010
First Posted: February 26, 2010
Last Update Posted: February 26, 2010
Last Verified: February 2010

Additional relevant MeSH terms:
Kidney Failure, Chronic
Renal Insufficiency, Chronic
Renal Insufficiency
Kidney Diseases
Urologic Diseases