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Comparison of Critical Flicker Fusion Versus Automated Visual Fields in the Detection of Early Glaucoma

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ClinicalTrials.gov Identifier: NCT01076114
Recruitment Status : Completed
First Posted : February 25, 2010
Last Update Posted : March 15, 2011
Sponsor:
Collaborator:
Nassau University Medical Center
Information provided by:
Northwell Health

Brief Summary:
The purpose of this study is to evaluate if critical flicker fusion is a more reliable method for detection of early glaucoma compared to automated visual fields in comparison to subjects without evidence of glaucoma or optic nerve disease.

Condition or disease
Glaucoma

Detailed Description:
Our hypothesis is that critical flicker fusion (CFF) is a more reliable method for detection of early glaucoma compared to automated visual fields in comparison to subjects without evidence of glaucoma or optic nerve disease. We aim to evaluate the structure of the optic nerve and compare it to results of visual fields and CFF. The CFF will also be correlated with intraocular pressure (IOP) measurements to observe if it may be more closely related than visual fields. This may become an additional tool to detect glaucoma in those with unreliable visual fields or who are unable to perform a visual field from physical or mental limitations.

Study Type : Observational
Actual Enrollment : 58 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Comparison of Critical Flicker Fusion vs. Automated Visual Fields in the Detection of Early Glaucoma
Study Start Date : February 2010
Actual Primary Completion Date : February 2011
Actual Study Completion Date : February 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Glaucoma
U.S. FDA Resources

Group/Cohort
Control
Patients with no evidence of glaucoma or as a suspect with normal intraocular pressure, normal cup to disc ratio with no other ocular pathology and a normal ophthalmic exam.
Glaucoma Suspect
Patients with abnormal cup to disc ratio or increased intraocular pressure (>21mm/Hg) with an otherwise normal ophthalmic exam.



Primary Outcome Measures :
  1. Difference of mean deviation of glaucoma suspects from controls between critical flicker fusion and automated visual fields. [ Time Frame: 1 visit (1 day) ]


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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Subjects will be selected from routine clinic patients seen at the Eye Center at Nassau University Medical Center, in East Meadow, NY.
Criteria

Inclusion:

  • Glaucoma Suspects:
  • Abnormal optic disc appearance with increased cup to disc ratio, or
  • Increased intraocular pressure >21 in either eye
  • Control Subjects:
  • Normal appearing optic discs
  • Normal intraocular pressure (<21)

Exclusion:

  • Other ocular pathology
  • History of seizures or epilepsy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01076114


Locations
United States, New York
Nassau University Medical Center
East Meadow, New York, United States, 11554
Sponsors and Collaborators
Northwell Health
Nassau University Medical Center
Investigators
Principal Investigator: Colin Scott, MD Nassau University Medical Center

Publications:

Responsible Party: Colin Scott, MD, Nassau University Medical Center
ClinicalTrials.gov Identifier: NCT01076114     History of Changes
Other Study ID Numbers: 09-320
First Posted: February 25, 2010    Key Record Dates
Last Update Posted: March 15, 2011
Last Verified: March 2011

Additional relevant MeSH terms:
Glaucoma
Ocular Hypertension
Eye Diseases