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Antimicrobial Drug Use and Resistant Staphylococcus Aureus

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01075451
Recruitment Status : Completed
First Posted : February 25, 2010
Last Update Posted : May 20, 2013
University HealthSystem Consortium
Cubist Pharmaceuticals LLC
Information provided by (Responsible Party):
Virginia Commonwealth University

Brief Summary:
The purpose of this investigation is to study the relationships between antimicrobial stewardship program efforts, antimicrobial drug use, and infection control efforts to the incidence rates of hospital acquired infections with Staphylococcus aureus in a sample of US academic medical center hospitals.

Condition or disease
Staphylococcus Aureus

Detailed Description:
Hospitalized patients can become infected with a variety of microorganisms, but infections caused by Staphylococcus aureus (i.e., "staph" infections) are particularly common. The main strategy to reduce the number of patients infected with Staph. aureus is to decrease cross-transmission from one patient to another. In addition, increasing evidence suggests that improvements in antimicrobial drug use--promoted by hospital Antimicrobial Stewardship programs (ASPs) -- may also favorably impact rates of Staph. aureus infections. While many Staphylococcal strains remain susceptible to an old drug called methicillin (methicillin-susceptible Staph aureus, or MSSA), many Staph. aureus are methicillin-resistant (MRSA). The drug of choice for MRSA has historically been vancomycin, and vancomycin is now the most commonly prescribed antibiotic in US teaching hospitals. Vancomycin-resistant Staph. aureus (VRSA) is still uncommon, but some Staph. aureus are developing "low level" resistance to vancomycin. These strains are often called S. aureus with MIC "creep" to vancomycin (SA-MICcreep), and Staphylococcus aureus with Heterogeneous Resistance to Vancomycin (hVISA), but the epidemiology, clinical significance and risk factors for these organisms are not well described. We will survey UHC participating hospitals to learn more about these organisms, the drug and ASP related risk factors, and whether hospitals are trying to identify these organisms.

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Study Type : Observational
Actual Enrollment : 41 participants
Observational Model: Ecologic or Community
Time Perspective: Retrospective
Official Title: Antimicrobial Drug Use and Resistant Staphylococcus Aureus in a Network of Academic Medical Center Hospitals.
Study Start Date : January 2010
Actual Primary Completion Date : May 2013
Actual Study Completion Date : May 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Antibiotics

Primary Outcome Measures :
  1. Association between Antimicrobial Stewardship Program and Infection Control efforts, antibacterial drug use and rates of hVISA and other resistant staphylococci. [ Time Frame: 2008 and 2009 ]
    Rates of hVISA and Staph.aureus with MIC creep to vancomycin

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Aggregate antibacterial drug use from adult inpatients at 60 UHC hospitals for 2006 - 2009

Inclusion Criteria:

  • NA

Exclusion Criteria:

  • NA

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01075451

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United States, Virginia
Virginia Commonwealth University School ofPharamcy
Richmond, Virginia, United States, 23298
Sponsors and Collaborators
Virginia Commonwealth University
University HealthSystem Consortium
Cubist Pharmaceuticals LLC
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Principal Investigator: Ron E Polk, Pharm.D. Virginia Commonwealth University
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Responsible Party: Virginia Commonwealth University Identifier: NCT01075451    
Other Study ID Numbers: PT104711
First Posted: February 25, 2010    Key Record Dates
Last Update Posted: May 20, 2013
Last Verified: May 2013
Keywords provided by Virginia Commonwealth University:
Staphylococcus aureus
Antimicrobial Stewardship
Antibacterial resistance