Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification PROJET " MOMIC " (MOMIC)
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ClinicalTrials.gov Identifier: NCT01075061 |
Recruitment Status :
Completed
First Posted : February 24, 2010
Last Update Posted : February 24, 2016
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Healthy | Other: healthy volunteers Other: Kallmann Other: Congenital Mirror Movement | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 40 participants |
Allocation: | Non-Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Official Title: | Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification : MOMIC |
Study Start Date : | February 2010 |
Actual Primary Completion Date : | July 2011 |
Actual Study Completion Date : | July 2011 |

Arm | Intervention/treatment |
---|---|
healthy volunteers
healthy volunteers
|
Other: healthy volunteers
morphological and functional brain MRI; transcranial magnetic stimulation |
Kallmann
Kallmann syndrome patients
|
Other: Kallmann
morphological and functional brain MRI; transcranial magnetic stimulation |
Congenital Mirror Movement
patients with CMM
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Other: Congenital Mirror Movement
morphological and functional brain MRI; transcranial magnetic stimulation |
- - To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM [ Time Frame: 08/2011 ]
- - To study patients with Kallmann syndrome and associated MM based on the same methods and hypothesis [ Time Frame: 08/2011 ]

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Ages Eligible for Study: | 11 Years to 82 Years (Child, Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Patients aged from 11 to 82 years
- Members of the family of interest displaying mirror movements or being obligatory asymptomatic carrier, without additional manifestation or malformation; or patient with genetically proven Kallmann syndrome and mirror movements.
- No contraindication for MRI or TMS study
Exclusion Criteria:
- inability to provide an informed consent
- Simultaneous participation in another clinical trial
- Treatment that modulate cortical excitability (for the TMS part of the study only)

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01075061
France | |
Fédération des Maladies du Système Nerveux, Hôpital Pitié Salpétrière | |
Paris, France, 75013 |
Principal Investigator: | Emmanuel ROZE, MD | Institut National de la Santé Et de la Recherche Médicale, France |
Responsible Party: | Institut National de la Santé Et de la Recherche Médicale, France |
ClinicalTrials.gov Identifier: | NCT01075061 |
Other Study ID Numbers: |
C09-06 2009-A00490-57 ( Registry Identifier: IDRCB ) |
First Posted: | February 24, 2010 Key Record Dates |
Last Update Posted: | February 24, 2016 |
Last Verified: | February 2016 |
Congenital mirror movement, physiopathology, imaging, transcranial magnetic stimulation, candidate gene |