Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification PROJET " MOMIC " (MOMIC)

This study has been completed.

Sponsor:

Information provided by (Responsible Party):

Institut National de la Santé Et de la Recherche Médicale, France

ClinicalTrials.gov Identifier:

NCT01075061

First received: February 4, 2010

Last updated: February 23, 2016

Last verified: February 2016

History of Changes

Purpose

Mirror movements are involuntary, symmetrical and simultaneous movements occurring on one side of the body that accompany controlateral voluntary movements. Congenital mirror movements (CMM) are characterized by childhood onset and the absence of additional manifestations. The aim of this study is to unravel the pathophysiology of the CMM that remains poorly elucidated. The combination of imaging studies and neurophysiological studies using transcranial magnetic stimulation in a homogeneous and relatively large group of patient is likely to allow us to better understand the underlying pathophysiology of the disorder. Using a linkage analysis approach we will try to identify a locus associated with CMM and related candidate genes.

Condition	Intervention
Healthy	Other: healthy volunteers Other: Kallmann Other: Congenital Mirror Movement


Study Type:	Interventional
Study Design:	Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Basic Science
Official Title:	Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification : MOMIC

Resource links provided by NLM:

Genetics Home Reference related topics: congenital mirror movement disorder

MedlinePlus related topics: Genes and Gene Therapy

Genetic and Rare Diseases Information Center resources: Congenital Mirror Movement Disorder

U.S. FDA Resources

Further study details as provided by Institut National de la Santé Et de la Recherche Médicale, France:

Primary Outcome Measures:

- To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM [ Time Frame: 08/2011 ]

Secondary Outcome Measures:

- To study patients with Kallmann syndrome and associated MM based on the same methods and hypothesis [ Time Frame: 08/2011 ]


Enrollment:	40
Study Start Date:	February 2010
Study Completion Date:	July 2011
Primary Completion Date:	July 2011 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
healthy volunteers healthy volunteers	Other: healthy volunteers morphological and functional brain MRI; transcranial magnetic stimulation
Kallmann Kallmann syndrome patients	Other: Kallmann morphological and functional brain MRI; transcranial magnetic stimulation
Congenital Mirror Movement patients with CMM	Other: Congenital Mirror Movement morphological and functional brain MRI; transcranial magnetic stimulation

Eligibility


Ages Eligible for Study:	11 Years to 82 Years (Child, Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Patients aged from 11 to 82 years
Members of the family of interest displaying mirror movements or being obligatory asymptomatic carrier, without additional manifestation or malformation; or patient with genetically proven Kallmann syndrome and mirror movements.
No contraindication for MRI or TMS study

Exclusion Criteria:

inability to provide an informed consent
Simultaneous participation in another clinical trial
Treatment that modulate cortical excitability (for the TMS part of the study only)

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01075061

Locations


France
Fédération des Maladies du Système Nerveux, Hôpital Pitié Salpétrière
Paris, France, 75013

Sponsors and Collaborators

Institut National de la Santé Et de la Recherche Médicale, France

Investigators


Principal Investigator:	Emmanuel ROZE, MD	Institut National de la Santé Et de la Recherche Médicale, France

More Information


Responsible Party:	Institut National de la Santé Et de la Recherche Médicale, France
ClinicalTrials.gov Identifier:	NCT01075061 History of Changes
Other Study ID Numbers:	C09-06 2009-A00490-57 ( Registry Identifier: IDRCB )
Study First Received:	February 4, 2010
Last Updated:	February 23, 2016

Keywords provided by Institut National de la Santé Et de la Recherche Médicale, France:


Congenital mirror movement, physiopathology, imaging, transcranial magnetic stimulation, candidate gene

ClinicalTrials.gov processed this record on July 19, 2017

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