Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification PROJET " MOMIC "
The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2011 by Institut National de la Santé Et de la Recherche Médicale, France.
Recruitment status was Recruiting
Recruitment status was Recruiting
Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by (Responsible Party):
Institut National de la Santé Et de la Recherche Médicale, France
ClinicalTrials.gov Identifier:
NCT01075061
First received: February 4, 2010
Last updated: December 29, 2011
Last verified: December 2011
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Purpose
Mirror movements are involuntary, symmetrical and simultaneous movements occurring on one side of the body that accompany controlateral voluntary movements. Congenital mirror movements (CMM) are characterized by childhood onset and the absence of additional manifestations. The aim of this study is to unravel the pathophysiology of the CMM that remains poorly elucidated. The combination of imaging studies and neurophysiological studies using transcranial magnetic stimulation in a homogeneous and relatively large group of patient is likely to allow us to better understand the underlying pathophysiology of the disorder. Using a linkage analysis approach we will try to identify a locus associated with CMM and related candidate genes.
| Condition | Intervention |
|---|---|
|
Healthy |
Other: healthy volunteers Other: Kallmann Other: Congenital Mirror Movement |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Basic Science |
| Official Title: | Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification : MOMIC |
Resource links provided by NLM:
Further study details as provided by Institut National de la Santé Et de la Recherche Médicale, France:
Primary Outcome Measures:
- - To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM [ Time Frame: 08/2011 ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- - To study patients with Kallmann syndrome and associated MM based on the same methods and hypothesis [ Time Frame: 08/2011 ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 45 |
| Study Start Date: | February 2010 |
| Estimated Study Completion Date: | August 2012 |
| Estimated Primary Completion Date: | August 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
healthy volunteers
healthy volunteers
|
Other: healthy volunteers
morphological and functional brain MRI; transcranial magnetic stimulation
|
|
Kallmann
Kallmann syndrome patients
|
Other: Kallmann
morphological and functional brain MRI; transcranial magnetic stimulation
|
|
Congenital Mirror Movement
patients with CMM
|
Other: Congenital Mirror Movement
morphological and functional brain MRI; transcranial magnetic stimulation
|
Eligibility| Ages Eligible for Study: | 11 Years to 82 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- Patients aged from 11 to 82 years
- Members of the family of interest displaying mirror movements or being obligatory asymptomatic carrier, without additional manifestation or malformation; or patient with genetically proven Kallmann syndrome and mirror movements.
- No contraindication for MRI or TMS study
Exclusion Criteria:
- inability to provide an informed consent
- Simultaneous participation in another clinical trial
- Treatment that modulate cortical excitability (for the TMS part of the study only)
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01075061
Please refer to this study by its ClinicalTrials.gov identifier: NCT01075061
Contacts
| Contact: Emmanuel ROZE, MD | 331 42 16 19 74 | emmanuel.roze@psl.aphp.fr |
Locations
| France | |
| Fédération des Maladies du Système Nerveux, Hôpital Pitié Salpétrière | Recruiting |
| Paris, France, 75013 | |
| Contact: Emmanuel ROZE, MD 331 42 16 19 74 emmanuel.roze@psl.aphp.fr | |
Sponsors and Collaborators
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
| Principal Investigator: | Emmanuel ROZE, MD | Institut National de la Santé Et de la Recherche Médicale, France |
More Information
No publications provided
| Responsible Party: | Institut National de la Santé Et de la Recherche Médicale, France |
| ClinicalTrials.gov Identifier: | NCT01075061 History of Changes |
| Other Study ID Numbers: | C09-06 |
| Study First Received: | February 4, 2010 |
| Last Updated: | December 29, 2011 |
| Health Authority: | France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis) |
Keywords provided by Institut National de la Santé Et de la Recherche Médicale, France:
|
Congenital mirror movement, physiopathology, imaging, transcranial magnetic stimulation, candidate gene |
ClinicalTrials.gov processed this record on February 27, 2015