Efficacy of Tart Cherry Juice to Reduce Pain and Inflammation Among Patients With Inflammatory Osteoarthritis
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ClinicalTrials.gov Identifier: NCT01073982 |
Recruitment Status :
Completed
First Posted : February 24, 2010
Last Update Posted : January 20, 2011
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Pain Inflammation | Dietary Supplement: tart cultivar Montmorency cherry juice | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 20 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Triple (Participant, Investigator, Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Efficacy of Tart Cherry Juice to Reduce Pain and Inflammation Among Patients With Inflammatory Osteoarthritis |
Study Start Date : | February 2010 |
Actual Primary Completion Date : | January 2011 |
Actual Study Completion Date : | January 2011 |

Arm | Intervention/treatment |
---|---|
Placebo Comparator: cherry flavored fruit drink |
Dietary Supplement: tart cultivar Montmorency cherry juice
21 ounces of experimental or placebo juice, consumed daily for 21 days. |
Experimental: tart cherry juice |
Dietary Supplement: tart cultivar Montmorency cherry juice
21 ounces of experimental or placebo juice, consumed daily for 21 days. |
- Primary outcomes include measurement of interleukin 10 (IL-10), CRP, and a specific group of cytokines that provide a generalized measurement of inflammatory activity, these include IL-6 and TNF-α. [ Time Frame: 6-8 months ]

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Ages Eligible for Study: | 30 Years to 70 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Diagnosed with inflammatory osteoarthritis
- In good general health
- Stable pattern of anti-inflammatory or pain relieving drug use for 3 months prior to study
- Ability and willingness to maintain consistent pattern of anti-inflammatory or pain relieving drug use during the course of the study, and to not seek any other treatment during the study
- Ability and willingness to consume juice or placebo drink for 21 consecutive days, and to participate in screening measures, including a blood draw, before and after the intervention period
Exclusion Criteria:
- Pregnancy
- Serious medical conditions such as recent heart attack or stroke, cancer, diabetes (type 1 and type 2), or gastrointestinal ulcers
- Individuals who have not been on a stable dose of pain medications or pain modalities for at least 3 months, including muscle relaxants, tender point anesthetic injections, systemic or intrabursal or intraarticular steroids, or any investigational drug/device in the prior 90 days
- Individuals who have used nonpharmacologic pain therapies including acupuncture, ultrasound, or transcutaneous electrical nerve stimulation within the past 30 days

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01073982
United States, Oregon | |
Oregon Health and Science University | |
Portland, Oregon, United States, 97239 |
Principal Investigator: | Kerry S Kuehl, MD, PhD | Oregon Health and Science University |
Responsible Party: | Kerry S. Kuehl MD PhD/Associate Professor, Oregon Health and Science University |
ClinicalTrials.gov Identifier: | NCT01073982 |
Other Study ID Numbers: |
e5825 |
First Posted: | February 24, 2010 Key Record Dates |
Last Update Posted: | January 20, 2011 |
Last Verified: | January 2011 |
pain inflammation osteoarthritis |
Osteoarthritis Inflammation Arthritis Joint Diseases |
Musculoskeletal Diseases Rheumatic Diseases Pathologic Processes |