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Semen Analysis After Proton Therapy for Prostate Cancer (PR08)

This study has been completed.
Information provided by (Responsible Party):
University of Florida Identifier:
First received: February 19, 2010
Last updated: April 5, 2016
Last verified: April 2016
The purpose of this study is to evaluate semen for changes following treatment with proton radiation therapy.

Condition Intervention
Prostate Cancer
Other: Semen analysis

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Official Title: Semen Analysis Following Definitive Treatment of Prostate Cancer With Proton Radiation Therapy Alone

Resource links provided by NLM:

Further study details as provided by University of Florida:

Primary Outcome Measures:
  • Post treatment sperm count [ Time Frame: 12 months after radiation therapy ]

Secondary Outcome Measures:
  • Compare changes in sperm motility, sperm morphology and semen PH. [ Time Frame: 12 months after radiation therapy ]
    This is composite measure

Enrollment: 31
Study Start Date: March 2010
Study Completion Date: July 2015
Primary Completion Date: July 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Semen analysis
Analysis of semen before and after proton radiation therapy.
Other: Semen analysis
Semen analysis before and after proton radiation therapy.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

- Diagnosis of low to intermediate risk prostate cancer and elected to have proton radiation therapy at University of Florida Proton Therapy Institute (UFPTI).

Exclusion Criteria:

  • Current use of Flomax, Hytrin, Cardura, Uroxatral, or Rapaflo.
  • History of vasectomy.
  • Current use of Lupron, Zoladex, Trelstar, Casodex, Eulexin.
  • Current use of Avodart or Proscar.
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Please refer to this study by its identifier: NCT01072513

United States, Florida
University of Florida Proton Therapy Institute
Jacksonville, Florida, United States, 32206
Sponsors and Collaborators
University of Florida
Principal Investigator: Bradford S Hoppe, MD, MPH University of Florida Proton Therapy Institute
  More Information

Additional Information:
Jang T, Bekelman J, Liu Y, et al. Visits to urologists and radiation oncologists prior to treatment decision making for clinically localized prostate cancer. Journal of Clinical Oncology 2007;25.

Responsible Party: University of Florida Identifier: NCT01072513     History of Changes
Other Study ID Numbers: UFPTI-0908-PR08
Study First Received: February 19, 2010
Last Updated: April 5, 2016

Keywords provided by University of Florida:
Semen Analysis, Prostate Cancer, Proton Radiation

Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Genital Diseases, Male
Prostatic Diseases processed this record on May 24, 2017