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The Effect of Obesity on Growth Hormone Response to Anaerobic Exercise

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ClinicalTrials.gov Identifier: NCT01070589
Recruitment Status : Unknown
Verified March 2012 by Meir Medical Center.
Recruitment status was:  Recruiting
First Posted : February 18, 2010
Last Update Posted : March 19, 2012
Sponsor:
Information provided by (Responsible Party):
Meir Medical Center

Study Description
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Brief Summary:
The aim of the present study is to asses the effect of obesity on anaerobic exercise's growth hormone (GH) response.

Condition or disease
Obesity

Detailed Description:
Exercise is a potent physiological stimulator of growth hormone (GH) release. GH is an important factor in the distribution of fat and lean tissue in the body. Previous studies suggested that the GH response to aerobic exercise may be attenuated by obesity. The effect of obesity on GH response to anaerobic effort is unclear. The aim of the present study is to asses the effect of obesity on anaerobic exercise's GH response. We will recruit 12 obese (BMI > 30) healthy adults and 12 age and gender matched normal weight (BMI < 25) controls. All the participants will conduct a "wingate" anaerobic test (30 seconds of intense effort against resistance calculated by the individual's body weight). Blood sample for GH level will be collected at 5 different time (0, 20, 30, 40 and 60 minutes after the test). We will compare the GH response in the two groups.

Study Design
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Study Type : Observational
Estimated Enrollment : 24 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Effect of Obesity on Growth Hormone Response to Anaerobic Exercise
Study Start Date : February 2010
Estimated Primary Completion Date : July 2012
Estimated Study Completion Date : July 2012

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Groups and Cohorts
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Group/Cohort
Group 1: Obese
BMI>30
Group 2: control
Group 2:Normal weight (BMI <25). age and gender matched.


Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy female Age 18-40 years
Criteria

Inclusion Criteria:

  • Healthy female
  • Age 18-40

Exclusion Criteria:

  • Male
  • Age <18, >40
  • Heart, Liver, Kidney or Hypophyseal disease
  • Medications that may alter GH secretion (eg Steroids, Eltroxin)
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01070589


Contacts
Contact: Noa rakover klein, MD 972-77-4920014 noa.rakover@gmail.com

Locations
Israel
Meir Medical Center Recruiting
Kfar Saba, Israel
Contact: Noa rakover klein, MD    974-9-7472630    NOA.KLEIN@clalit.org.il   
Principal Investigator: Noa Klein, MD         
Sponsors and Collaborators
Meir Medical Center
Investigators
Principal Investigator: Allon Eliakim, MD Meir Medical Center
More Information
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Responsible Party: Meir Medical Center
ClinicalTrials.gov Identifier: NCT01070589     History of Changes
Other Study ID Numbers: MMC01922009CTIL
First Posted: February 18, 2010    Key Record Dates
Last Update Posted: March 19, 2012
Last Verified: March 2012

Keywords provided by Meir Medical Center:
Obesity
Growth hormone secretion
Anaerobic exercise

Additional relevant MeSH terms:
Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
 Signs and Symptoms
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs