Determining the Lymphokine Activated Killer (LAK) Cytotoxicity Present in Patients Undergoing Interleukin-2 Therapy (LAK)
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ClinicalTrials.gov Identifier: NCT01068470
Recruitment Status :
(PI left the institution)
Therapy with Interleukin-2 stimulates lymphocytes in humans to become Lymphokine-activated Killer cells (LAK). This study will determine if these killer cells are able to kill certain standard cell-lines in the laboratory.
Condition or disease
Blood samples will be taken from patients undergoing outpatient Interleukin-2 therapy to measure the LAK cytotoxicity at baseline, after 1 cycle of therapy and 2 months later. The LAK cytotoxicity assay will be a standard colorimetric assay that measures lactic dehydrogenase release from lysed cells.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients undergoing Interleukin-2 therapy under the care of physicians at Loma Linda University Cancer Center
Patients must be undergoing Interleukin-2 therapy under the care of physicians at Loma Linda University Cancer Center
Patients must sign and give written informed consent in accordance with institutional and federal guidelines
Patients not undergoing Interleukin-2 therapy under the care of physicians at Loma Linda University Cancer Center