Effect of Exercise on Endothelial Function and Vascular Compliance in Chronic Kidney Disease
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|ClinicalTrials.gov Identifier: NCT01068314|
Recruitment Status : Completed
First Posted : February 12, 2010
Last Update Posted : February 27, 2014
|Condition or disease||Intervention/treatment||Phase|
|Kidney Failure, Chronic||Other: Repetitive arm exercise||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Effect of Forearm Exercise on Flow Mediated Vasodilation Prior to Arteriovenous Fistula Placement for Hemodialysis|
|Study Start Date :||January 2007|
|Actual Primary Completion Date :||May 2008|
|Actual Study Completion Date :||June 2010|
Experimental: Repetitive handgrip exercise
After baseline testing and randomization, subjects in this group are instructed to perform the intervention: daily repetitive handgrip exercise with upper arm compression band. Brachial artery endothelial function and venous compliance are tested at baseline and 6 weeks.
Other: Repetitive arm exercise
After baseline testing and randomization, subjects in this group are instructed to perform repetitive handgrip exercise with an upper arm compression band until arm fatigue occurs. After resting 1 minute this exercise is repeated 9 times daily for 6 weeks.
No Intervention: No arm exercise
Time control. Subjects do usual activities without any exercise intervention. Brachial artery endothelial function and venous compliance are tested at baseline and 6 weeks.
- Brachial artery flow-mediated dilatation [ Time Frame: 6 weeks ]
- Forearm venous compliance by plethysmography [ Time Frame: 6 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01068314
|United States, Iowa|
|University of Iowa General Clinical Research Center|
|Iowa City, Iowa, United States, 52242|
|Principal Investigator:||Bradley S Dixon, MD||University of Iowa|