Bronchodilator Responsiveness in Healthy Young Adults Using Forced Oscillations Technique (FOT)
|ClinicalTrials.gov Identifier: NCT01067534|
Recruitment Status : Completed
First Posted : February 11, 2010
Last Update Posted : January 19, 2011
Studies evaluating response to bronchodilation in flow-volume spirometry and/or by forced oscillations technique (FOT), have been conduced in subjects with obstructive airways diseases. Less is known about bronchodilation responses, assessed by both spirometry and FOT in healthy young subjects.
The purpose of the present study is
- to determine the range of the bronchodilation response in terms of changes in selected spirometric parameters in healthy non-smoking young adults, for identifying normal response after an inhaled bronchodilatory agent versus placebo, and its anthropometric and spirometric determinants
- to determine the range and characteristics of bronchodilation response using pseudorandom FOT in healthy non-smoking young adults, for identifying normal response after an inhaled bronchodilatory agent versus placebo, and its anthropometric and oscillometric determinants.
- to compare and correlate eventual changes in spirometric and oscillometric parameters.
The investigators hypothesize that exists a normal variation in spirometric and oscillometric parameters after bronchodilation, and that these parameters are correlated.
|Condition or disease||Intervention/treatment||Phase|
|Bronchodilation||Drug: Salbutamol||Not Applicable|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||100 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Assessment of Bronchodilator Responsiveness in Healthy Young Adults Using Forced Oscillations|
|Study Start Date :||February 2010|
|Actual Primary Completion Date :||January 2011|
|Actual Study Completion Date :||January 2011|
- Bronchodilation responses, assessed by both spirometry and FOT, in healthy young subjects after receiving salbutamol or placebo [ Time Frame: 15 minutes after inhalation of salbutamol or placebo ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01067534
|University Hospital of Patras|
|Patras, Greece, 26504|
|Study Director:||Michael Anthracopoulos, MD||University Hospital of Patras, Greece|
|Principal Investigator:||Sotirios Fouzas, MD||University Hospital of Patras, Greece|
|Principal Investigator:||Konstantinos Bolis, MD||University Hospital of Patras, Greece|