Chronic Obstructive Pulmonary Disease (COPD) and Osteoporosis
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|ClinicalTrials.gov Identifier: NCT01067248|
Recruitment Status : Completed
First Posted : February 11, 2010
Last Update Posted : July 29, 2015
|Condition or disease|
|Pulmonary Disease, Chronic Obstructive Osteoporosis|
Chronic obstructive pulmonary disease (COPD) is defined as a preventable and treatable disease with significant extrapulmonary effects. Osteoporosis is recognized as one of these extrapulmonary consequences. It results in increased risk of fracture and thereby an increased morbidity and mortality. Nowadays it is believed that the patho-physiology of osteoporosis is multi-factorial. However, which factors are most important in patients with COPD is still not clear.
The main objective is to study important factors in the patho-physiology of osteoporosis in patients with COPD. Therefore, we will study biological markers in plasma and urine and correlate them to markers of bone turnover and clinical data.
The present study will be an observational, cross-sectional study.
|Study Type :||Observational|
|Actual Enrollment :||120 participants|
|Official Title:||Patho-physiology of Osteoporosis in Patients With Chronic Obstructive Pulmonary Disease (COPD)|
|Study Start Date :||January 2010|
|Actual Primary Completion Date :||December 2012|
|Actual Study Completion Date :||December 2012|
The subjects are divided into 6 groups of 20 subjects each, I: COPD patients with osteoporosis based on T-score and without vertebral fractures, II: COPD patients with osteoporosis based on T-score and vertebral fractures, III: COPD patients with vertebral fractures and without osteoporosis based on T-score, IV: COPD patients without osteoporosis based on T-score and without vertebral fractures, V: healthy controls with osteoporosis based on T-score and without vertebral fractures, VI: healthy controls without osteoporosis based on T-score and without vertebral fractures.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01067248
|Principal Investigator:||Emiel Wouters, MD, PhD, prof||Maastricht University Medical Center|