Chronic Obstructive Pulmonary Disease (COPD) and Osteoporosis
Pulmonary Disease, Chronic Obstructive
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Patho-physiology of Osteoporosis in Patients With Chronic Obstructive Pulmonary Disease (COPD)|
|Study Start Date:||January 2010|
|Study Completion Date:||December 2012|
|Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
The subjects are divided into 6 groups of 20 subjects each, I: COPD patients with osteoporosis based on T-score and without vertebral fractures, II: COPD patients with osteoporosis based on T-score and vertebral fractures, III: COPD patients with vertebral fractures and without osteoporosis based on T-score, IV: COPD patients without osteoporosis based on T-score and without vertebral fractures, V: healthy controls with osteoporosis based on T-score and without vertebral fractures, VI: healthy controls without osteoporosis based on T-score and without vertebral fractures.
Chronic obstructive pulmonary disease (COPD) is defined as a preventable and treatable disease with significant extrapulmonary effects. Osteoporosis is recognized as one of these extrapulmonary consequences. It results in increased risk of fracture and thereby an increased morbidity and mortality. Nowadays it is believed that the patho-physiology of osteoporosis is multi-factorial. However, which factors are most important in patients with COPD is still not clear.
The main objective is to study important factors in the patho-physiology of osteoporosis in patients with COPD. Therefore, we will study biological markers in plasma and urine and correlate them to markers of bone turnover and clinical data.
The present study will be an observational, cross-sectional study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01067248
|Principal Investigator:||Emiel Wouters, MD, PhD, prof||Maastricht University Medical Center|