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Pneumatic Compression Stockings During Hemodialysis

This study has been completed.
Information provided by (Responsible Party):
Dr Jennifer MacRae, University of Calgary Identifier:
First received: February 9, 2010
Last updated: December 12, 2012
Last verified: December 2012
This study aims to determine the effect of pneumatic compression devices (PCDs) on central blood volume in hemodialysis patients. We hypothesize that PCDs will help maintain central blood volume, and therefore prevent sudden decreases in blood pressure during hemodialysis.

Condition Intervention
Hemodialysis Device: Pneumatic Compression Stockings

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: The Effect of Pneumatic Compression Stockings on Hemodynamic Parameters in Hemodialysis Patients: A Randomized Crossover Trial

Resource links provided by NLM:

Further study details as provided by Dr Jennifer MacRae, University of Calgary:

Primary Outcome Measures:
  • Central blood volume [ Time Frame: pre and post hemodialysis ]

Secondary Outcome Measures:
  • cardiac output [ Time Frame: pre and post hemodialysis ]
  • cardiac index [ Time Frame: pre and post hemodialysis ]
  • systemic vascular resistance [ Time Frame: pre and post hemodialysis ]
  • intracellular fluid volume [ Time Frame: pre and post hemodialysis ]
  • extracellular fluid volume [ Time Frame: pre and post hemodialysis ]
  • total body water [ Time Frame: pre and post hemodialysis ]

Enrollment: 51
Study Start Date: November 2008
Study Completion Date: August 2012
Primary Completion Date: February 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Pneumatic compression stockings Device: Pneumatic Compression Stockings
Thigh-high pneumatic compression stockings


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • on hemodialysis at least 3 months
  • on hemodialysis at least 3 times per week

Exclusion Criteria:

  • dialyzing with a central venous catheter
  • vascular access dysfunction
  • peripheral vascular disease
  • active medical issue
  • unable to provide informed consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT01067170

Canada, Alberta
University of Calgary
Calgary, Alberta, Canada, T2N 2T9
Sponsors and Collaborators
University of Calgary
Principal Investigator: Jennifer M MacRae, MD MSc University of Calgary
  More Information

Responsible Party: Dr Jennifer MacRae, Director, Hemodialysis and Vascular Access, University of Calgary Identifier: NCT01067170     History of Changes
Other Study ID Numbers: E-21937
Study First Received: February 9, 2010
Last Updated: December 12, 2012

Keywords provided by Dr Jennifer MacRae, University of Calgary:
Intradialytic hypotension processed this record on August 18, 2017