Postprandial Inflammatory Response in Healthy Men: Effect of Dietary Fat Source, Obesity and Age
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01066091|
Recruitment Status : Completed
First Posted : February 10, 2010
Last Update Posted : March 25, 2015
The nature of dietary lipids, age and perivisceral adiposity could alter the postprandial inflammatory response. It is supposed that there is a relationship between the postprandial inflammatory response and the repartition of fat and lean mass, which could partially explain the muscle mass loss with age.
The aim of this study is to compare the inflammatory response of a normal meal or high fat meal (from different fatty acids sources) between young lean and young obese and aged lean and aged obese men.
|Condition or disease||Intervention/treatment||Phase|
|Healthy Obesity||Other: Mashed potatoes Other: Mashed potatoes + Oleic acid Other: mashed potatoes + Palmitic acid||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||32 participants|
|Intervention Model:||Crossover Assignment|
|Primary Purpose:||Health Services Research|
|Official Title:||Postprandial Inflammatory Response in Healthy Men: Effect of Dietary Fat Source, Obesity and Age|
|Study Start Date :||March 2010|
|Actual Primary Completion Date :||December 2010|
|Actual Study Completion Date :||January 2011|
Placebo Comparator: mashed potatoes
Mashed potatoes is composed of potatoes and Skim milk powder.
Other: Mashed potatoes
Mashed potatoes: Potatoes + Skim milk powder
Experimental: Mashed potatoes + Oleic Acid
The test meal is mashed potatoes with 1g/Kg of weight of lipids with 75% of Oleic Acid
Other: Mashed potatoes + Oleic acid
Mashed potatoes with 1g/Kg of weight, of lipids with 75% of Oleic Acid
Experimental: Mashed potatoes + Palmitic Acid
The test meal is mashed potatoes with 1g/Kg of weight of lipids with 39% of saturated fat with 32% of palmitic acid.
Other: mashed potatoes + Palmitic acid
Mashed potatoes with 1g/Kg of weight, of lipids with 32% of palmitic acid
- Inflammatory profile by interleukin-6 (IL6) concentration in plasma. [ Time Frame: six times per day (kinetic: T0 to T480) on three interventional days ]
- Muscular strength, Body composition [ Time Frame: Once at the first and at the last visit ]
- Total plasma lipids (total cholesterol, HDL-Cholesterol, LDL-cholesterol, Triglycerides (TG), non-esterified fatty acid, Plasma hormonal profile, Plasma inflammatory profile, Markers of Endothelial function, Plasma lipopolysaccharide concentration. [ Time Frame: Six times per day (kinetic: T0 to T480), on three interventional days ]
- Pro-inflammatory cytokines expression in subcutaneous adipose tissue [ Time Frame: Twice per day (before the meal and 6 hours after), on three interventional days ]
- Urinary metabolomic profile [ Time Frame: Three times per days (T0,T240,T480), on three interventional days ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01066091
|Human nutrition laboratory|
|Clermont-ferrand, Auvergne, France, 63000|
|Principal Investigator:||Yves Boirie, MD/PhD||CRNH|
|Study Director:||Stephane Walrand, PhD||Institut National de la Recherche Agronomique|