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Pangenomic Study During Alcoholic Cirrhosis (CDCHC)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2010 by Nantes University Hospital.
Recruitment status was:  Recruiting
Information provided by:
Nantes University Hospital Identifier:
First received: February 8, 2010
Last updated: August 12, 2011
Last verified: April 2010

Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome.

The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition.

In this study, the investigators will identify predictives genetic polymorphism of HCC.

Condition Intervention
Alcoholic Cirrhosis Genetic: DNA extraction

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Genetical Predisposition in Hepatocellular Carcinoma : Pangenomic Link Study During Alcoholic Cirrhosis

Resource links provided by NLM:

Further study details as provided by Nantes University Hospital:

Primary Outcome Measures:
  • Existence of HCC and Pangenomic analysis of DNA polymorphism
    Existence of HCC and determination of which genetic polymorphism are predisposing to HCC or preventing for HCC

Secondary Outcome Measures:
  • cirrhosis severity (compensated or not)
    Analysis of the genetic polymorphism involved in the severity of cirrhosis

Biospecimen Retention:   Samples With DNA
2 blood samples of 5ml for DNA extraction

Estimated Enrollment: 600
Study Start Date: May 2008
Estimated Study Completion Date: May 2012
Estimated Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
alcoholic cirrhosis with viral infection
patient with alcoholic cirrhosis with viral infection (300 patients)
Genetic: DNA extraction
DNA extraction of blood sample for DNAship analysis
alcoholic cirrhosis without viral infection
patient with alcoholic cirrhosis without viral infection
Genetic: DNA extraction
DNA extraction of blood sample for DNAship analysis


Ages Eligible for Study:   35 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

2 groups with 2 subgroups:

  • patient with HCC
  • HCC with Child A
  • HCC with Child B/C
  • patient without HCC
  • Child A without HCC
  • Child B/C without HCC

Inclusion Criteria:

  • 35 to 70 years old
  • Compensated cirrhosis or not
  • Caucasian origin of the parents
  • Patient with cirrhosis (histological proof or obvious)

Exclusion Criteria:

  • HIV, HBV, HCV positive
  • Known Homozygotia (C282Y+/+)
  • Important hepatocytary iron overload for patient with resection
  • HCC non histologically prooved
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01065233

Contact: Cyrille Feray, MD 0240087529

Nantes UH Recruiting
Nantes, France, 44000
Contact: Cyrille Feray, MD    0240087529   
Principal Investigator: Cyrille Feray, MD         
Jean Verdier UH Recruiting
Paris, France, 75000
Contact: Jean-Claude Trichet, MD    01 48 02 62 80   
Principal Investigator: Jean-Claude Trinchet, MD         
Paul Brousse UH Recruiting
Paris, France, 75000
Contact: Didier Samuel, MD    0145593199   
Principal Investigator: Didier Samuel, MD         
Rennes UH Recruiting
Rennes, France, 35000
Contact: Michel Messner, MD    02 99 28 42 97   
Sponsors and Collaborators
Nantes University Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Anne Omnes, CPRC - NantesUH Identifier: NCT01065233     History of Changes
Other Study ID Numbers: 07/8-M
Study First Received: February 8, 2010
Last Updated: August 12, 2011

Additional relevant MeSH terms:
Liver Cirrhosis
Liver Cirrhosis, Alcoholic
Pathologic Processes
Liver Diseases
Digestive System Diseases
Liver Diseases, Alcoholic
Alcohol-Induced Disorders
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders processed this record on August 22, 2017