Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Fractional Flow Reserve (FFR) Stability in Non-Culprit Vessels at ST Elevation Myocardial Infarction(STEMI)

This study has been completed.
University of British Columbia
Information provided by (Responsible Party):
David Wood, MD, Cardiology Research UBC Identifier:
First received: February 8, 2010
Last updated: September 8, 2014
Last verified: September 2014
It has been shown that if it can be accomplished within a 90 minute "door to balloon" time, opening an artery in an acute heart attack situation (ST elevation myocardial infarction or STEMI) is best treated with balloon angioplasty and stenting (percutaneous coronary intervention or PCI). In these situations, there may be narrowings other than the one causing the heart attack (culprit) and studies have shown that delaying treatment of other narrowings for follow-up procedure is better than intervening at the time of the acute MI.

Condition Intervention
Myocardial Infarction
Procedure: FFR (Fractional Flow Reserve)

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Fractional Flow Reserve Stability Study of Non-culprit Vessels in Patients With ST Elevation Myocardial Infarction

Resource links provided by NLM:

Further study details as provided by Cardiology Research UBC:

Primary Outcome Measures:
  • FFR measurement [ Time Frame: Baseline and repeated at 4-6 weeks ]

Enrollment: 48
Study Start Date: March 2010
Study Completion Date: September 2014
Primary Completion Date: September 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: FFR measurement Procedure: FFR (Fractional Flow Reserve)
Single FFR measurement in non-culprit vessel

  Show Detailed Description


Ages Eligible for Study:   19 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Any patient >18 years of age with an acute STEMI eligible for primary PCI
  2. Readily identifiable culprit vessel and at least one other (non-culprit) vessel of a least >50% severity by traditional angiography
  3. Deemed appropriate for a strategy of delayed revascularization of the NCV.

Exclusion Criteria:

  1. Inability to provide informed consent
  2. Cardiogenic shock or severe (Killip III) congestive heart failure
  3. Hemodynamically significant ventricular arrhythmias
  4. Severe recurrent clinically significant ischemia following successful PCI of the IRA
  5. Thrombocytopenia (platelet count <100,000)
  6. Severe anemia (HgB <100 g/L)
  7. Major bleeding during hospitalization of the index STEMI
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01065103

Canada, British Columbia
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9
St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Sponsors and Collaborators
Cardiology Research UBC
University of British Columbia
Principal Investigator: David Wood, MD University of British Columbia
  More Information

Canadian Cardiovascular Society.; American Academy of Family Physicians.; American College of Cardiology.; American Heart Association., Antman EM, Hand M, Armstrong PW, Bates ER, Green LA, Halasyamani LK, Hochman JS, Krumholz HM, Lamas GA, Mullany CJ, Pearle DL, Sloan MA, Smith SC Jr, Anbe DT, Kushner FG, Ornato JP, Pearle DL, Sloan MA, Jacobs AK, Adams CD, Anderson JL, Buller CE, Creager MA, Ettinger SM, Halperin JL, Hunt SA, Lytle BW, Nishimura R, Page RL, Riegel B, Tarkington LG, Yancy CW. 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2008 Jan 15;51(2):210-47. doi: 10.1016/j.jacc.2007.10.001. Review. Erratum in: J Am Coll Cardiol. 2008 Mar 4;51(9):977.
Patel MR, Dehmer GJ, Hirshfeld JW, Smith PK, Spertus JA; American College of Cardiology Foundation Appropriateness Criteria Task Force.; Society for Cardiovascular Angiography and Interventions.; Society of Thoracic Surgeons.; American Association for Thoracic Surgery.; American Heart Association, and the American Society of Nuclear Cardiology Endorsed by the American Society of Echocardiography.; Heart Failure Society of America.; Society of Cardiovascular Computed Tomography.. ACCF/SCAI/STS/AATS/AHA/ASNC 2009 Appropriateness Criteria for Coronary Revascularization: a report by the American College of Cardiology Foundation Appropriateness Criteria Task Force, Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, American Association for Thoracic Surgery, American Heart Association, and the American Society of Nuclear Cardiology Endorsed by the American Society of Echocardiography, the Heart Failure Society of America, and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol. 2009 Feb 10;53(6):530-53. doi: 10.1016/j.jacc.2008.10.005.

Responsible Party: David Wood, MD, Principal Investigator, Cardiology Research UBC Identifier: NCT01065103     History of Changes
Other Study ID Numbers: H09-03435
Study First Received: February 8, 2010
Last Updated: September 8, 2014

Keywords provided by Cardiology Research UBC:
Primary angioplasty
Non-culprit vessel at STEMI
Fractional Flow Reserve
ST-elevation myocardial infarction
Fractional Flow Reserve in non-culprit vessel at STEMI

Additional relevant MeSH terms:
Myocardial Infarction
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Glucuronyl glucosamine glycan sulfate
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on May 25, 2017