Bright Light: A Novel Treatment for Anxiety
The primary aim of this research was to examine the influence of bright light on anxiety in high-anxious young adults. In an acute exposure study, participants were randomly assigned to 45 min of either (1) bright light (3,000 lux) or (2) a placebo inactivated negative ion generator. Treatments were initiated ≤1 hr after awakening. At 10 min before and 30 min after the treatments, state anxiety, mood, and blood pressure were assessed.
Following the acute exposure study, participants performed a 5-week study. Following a a 1-week baseline, participants were randomly assigned to four weeks of daily exposure to either (1) bright light (45 min/day; 3,000 lux) or (2) placebo inactivated negative ion generator, which were initiated ≤1 hr after awakening. Before and after the experiment, clinical ratings were conducted with the Hamilton Anxiety Scale, the Hamilton Depression Scale, and the Clinical Global Impressions scale (CGI). Following baseline, and following each week of treatment, blood pressure, as well as questionnaires for state anxiety, depression, mood, sleep, and side effects were assessed.
|Anxiety Depression Sleep||Device: Litebook Bright Light Box Device: Litebook inactivated negation ion generator (the placebo)||Phase 1|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:||Bright Light: A Novel Treatment for Anxiety|
- Spielberger State Anxiety Inventory [ Time Frame: 5 weeks ]
- Hamilton Anxiety [ Time Frame: 5 weeks ]
- Beck Depression Inventory [ Time Frame: 5 weeks ]
- Pittsburgh Sleep Quality Inventory [ Time Frame: 5 weeks ]
|Study Start Date:||October 2006|
|Study Completion Date:||December 2007|
|Primary Completion Date:||December 2007 (Final data collection date for primary outcome measure)|
No Intervention: Baseline
1 week period, in which subjects followed usual schedule, though they were asked to maintain a fairly stable sleep schedule. The baseline period was used for comparison with the experimental intervention.
Experimental: Experimental Intervention
Randomized exposure to the 4-week experimental treatments.
Device: Litebook Bright Light Box
Four weeks of daily exposure to bright light (3,000 lux) for 45 min/day, beginning within 60 min of arising.
Other Name: PhototherapyDevice: Litebook inactivated negation ion generator (the placebo)
Four weeks of daily exposure to inactivated negative ion generator for 45 min/day, beginning within 60 min of arising
Other Name: Placebo
Please refer to this study by its ClinicalTrials.gov identifier: NCT01064700
|United States, South Carolina|
|Chronobiology Lab, University of South Carolina|
|Columbia, South Carolina, United States, 29208|
|Principal Investigator:||Shawn D Youngstedt||University of Southern California|