Intrauterine Human Chorionic Gonadotrophins (hCG) and Endometrial Treg Cells
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|ClinicalTrials.gov Identifier: NCT01064219|
Recruitment Status : Completed
First Posted : February 8, 2010
Last Update Posted : November 5, 2013
|Condition or disease||Intervention/treatment|
|Infertility||Drug: human chorionic gonadotrophin|
Aim of the work:
To study the effect of intrauterine injection of human chorionic gonadotrophin on the endometrial T regulatory cells (Treg cells)and the electromicroscopic endometrial characteristics.
It has been demonstrated that regulatory T cells expand during pregnancy and are present at the feto-maternal interface at very early stages in pregnancy.
Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation.
Intrauterine injection of 100 IU hCG will be done followed by endometrial biopsy to check for Treg cells and pinopodes.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Outcomes Assessor)|
|Official Title:||The Effect of Intrauterine Injection of Human Chorionic Gonadotrophins (hCG) on the Endometrial T-regulatory Cells and the Electronmicroscopic Endometrial Characteristics|
|Study Start Date :||February 2010|
|Primary Completion Date :||December 2010|
|Study Completion Date :||December 2010|
Experimental: intrauterine hCG
intrauterine injection of 100 hCG followed by endometrial biopsy
Drug: human chorionic gonadotrophin
intrauterine injection of 100 IU hCG followed by endometrial biopsy .
Other Name: choriomon
- the presence of Treg cells and pinopodes in the endometrium [ Time Frame: 4 weeks ]
- pregnancy rate [ Time Frame: 4 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01064219
|Principal Investigator:||Ragaa Mansour, MD,PhD||The Egyptian IVF-ET Center|