Intrauterine Human Chorionic Gonadotrophins (hCG) and Endometrial Treg Cells
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Diagnostic
|Official Title:||The Effect of Intrauterine Injection of Human Chorionic Gonadotrophins (hCG) on the Endometrial T-regulatory Cells and the Electronmicroscopic Endometrial Characteristics|
- the presence of Treg cells and pinopodes in the endometrium [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]
- pregnancy rate [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]
|Study Start Date:||February 2010|
|Study Completion Date:||December 2010|
|Primary Completion Date:||December 2010 (Final data collection date for primary outcome measure)|
Experimental: intrauterine hCG
intrauterine injection of 100 hCG followed by endometrial biopsy
Drug: human chorionic gonadotrophin
intrauterine injection of 100 IU hCG followed by endometrial biopsy .
Other Name: choriomon
Aim of the work:
To study the effect of intrauterine injection of human chorionic gonadotrophin on the endometrial T regulatory cells (Treg cells)and the electromicroscopic endometrial characteristics.
It has been demonstrated that regulatory T cells expand during pregnancy and are present at the feto-maternal interface at very early stages in pregnancy.
Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation.
Intrauterine injection of 100 IU hCG will be done followed by endometrial biopsy to check for Treg cells and pinopodes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01064219
|Principal Investigator:||Ragaa Mansour, MD,PhD||The Egyptian IVF-ET Center|