Teriparatide for Improved Knee Prosthesis Fixation

This study has been completed.
Information provided by (Responsible Party):
Per Aspenberg, University Hospital, Linkoeping
ClinicalTrials.gov Identifier:
First received: February 4, 2010
Last updated: June 17, 2013
Last verified: June 2013

The investigators will study how well knee joint prostheses become fixed to the bone when patients get teriparatide, compared to placebo. Measurements will use high resolution 3D radiography (radiostereometry, RSA).

Condition Intervention Phase
Osteoarthritis of the Knee
Drug: teriparatide
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Prevention

Resource links provided by NLM:

Further study details as provided by University Hospital, Linkoeping:

Primary Outcome Measures:
  • Migration as measured by RSA maximal total point motion. [ Time Frame: 2 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 60
Study Start Date: February 2010
Study Completion Date: June 2013
Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Teriparatide 20 microgram daily for 2 months Drug: teriparatide
Placebo Comparator: Placebo Drug: teriparatide


Ages Eligible for Study:   60 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Osteoarthritis of the knee planned for prosthesis surgery

Exclusion Criteria:

  • Poor health, drugs affecting bone metabolism.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01063504

Motala hospital
Motala, Sweden
Sponsors and Collaborators
University Hospital, Linkoeping
  More Information

No publications provided

Responsible Party: Per Aspenberg, professor, University Hospital, Linkoeping
ClinicalTrials.gov Identifier: NCT01063504     History of Changes
Other Study ID Numbers: PTHKnee
Study First Received: February 4, 2010
Last Updated: June 17, 2013
Health Authority: Sweden: Ministry of education and research

Additional relevant MeSH terms:
Osteoarthritis, Knee
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Bone Density Conservation Agents
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on October 09, 2015