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Prospective Assessment of Adolescent Drinking Trajectories With Computer-Assisted Self-administration of Ethanol (CASE)

This study has been completed.
Indiana University School of Medicine
Information provided by (Responsible Party):
Technische Universität Dresden Identifier:
First received: February 4, 2010
Last updated: January 20, 2016
Last verified: January 2016
The Computer-Assisted Self-administration of Ethanol (CASE)will be administered twice, at the ages 18 and 20, in a prospective study of 80 adolescents living in the Dresden area. The sample will be recruited for a differential family history of alcoholism (FHA) and gender, with inventories of alcohol use disorder (AUD) symptoms and personal recent drinking history (RDH) obtained prior to each CASE session.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Collaboration on Alcohol Self Administration in Adolescents and Young Adults - Specific Aim 1: Assess the Initial Slope of Adolescent Drinking Trajectories, Beginning at the Age of Eighteen

Resource links provided by NLM:

Further study details as provided by Technische Universität Dresden:

Primary Outcome Measures:
  • Alcohol consumption [ Time Frame: 2 years ]
    Alcohol consumption, as measured by a Timeline Followback Interview and experimental Self-Administration.

Secondary Outcome Measures:
  • Alcohol Use Disorders [ Time Frame: 2 years ]

Enrollment: 96
Study Start Date: June 2010
Study Completion Date: December 2015
Primary Completion Date: March 2012 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 19 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Residents living within 15 km (9.5 miles) from downtown Dresden

Inclusion Criteria:

  • (a) male and female Caucasian volunteers aged 18 years/0 months to 19 years/11 months;
  • (b) written informed consent by the subject;
  • (c) habitual social drinking during the two months preceding participation, defined by at least one drinking day in any two weeks-interval;
  • (d) at least one prior experience of alcohol intoxication
  • (e) being able to abstain from tobacco use for four hours without developing nicotine withdrawal symptoms;
  • (f) effective contraception in female participants;
  • (g) consenting to abstain from any illegal substance use for 2 weeks prior to participation;
  • (h) living within 15 km (9.5 miles) from downtown Dresden;
  • (i) sufficient information concerning alcohol use in both parents and in at least four second-degree relatives

Exclusion Criteria:

  • (a) prior medical treatment due to alcohol use;
  • (b) current or prior history of any serious disease, including CNS, cardiovascular, respiratory, gastrointestinal, hepatic, renal, endocrine, alcohol or drug dependence, but not alcohol abuse;
  • (c) current history of Axis-I psychiatric illness, including premenstrual dysphoric disorder;
  • (d) current or prior history of alcohol-induced flushing reactions;
  • (e) positive urine screen for cannabinoids, cocaine, amphetamines, opiates, or benzodiazepines;
  • (f) light or non-drinkers: averaging less than 2 standard drinks per week in the preceding two months;
  • (g) intention to become pregnant
  • (h) pregnancy or positive urine pregnancy screening or breast-feeding;
  • (i) any alcohol intake on the test day or the day before;
  • (k) use of medications known to interact with alcohol within 2 weeks of the study;
  • (l) positive hepatitis or HIV at screening, provided the subject consented to these tests
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Please refer to this study by its identifier: NCT01063166

Universitaetsklinikum Carl Gustav Carus at the Technische Universitaet Dresden
Dresden, Saxony, Germany, 01307
Sponsors and Collaborators
Technische Universität Dresden
Indiana University School of Medicine
Principal Investigator: Ulrich S Zimmermann, Dr. Universitaetsklinikum Carl Gustav Carus at the Technische Universitaet Dresden
  More Information

Responsible Party: Technische Universität Dresden Identifier: NCT01063166     History of Changes
Other Study ID Numbers: U01 AA017900 SA1
Study First Received: February 4, 2010
Last Updated: January 20, 2016

Additional relevant MeSH terms:
Underage Drinking
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Alcohol Drinking
Drinking Behavior processed this record on August 21, 2017