Functional Neuroimaging of Cortical Plasticity in the Human Visual System

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 2016 by Baylor College of Medicine
Sponsor:
Collaborator:
Brigham and Women's Hospital, Harvard University
Information provided by (Responsible Party):
Stelios Smirnakis, Baylor College of Medicine
ClinicalTrials.gov Identifier:
NCT01062672
First received: February 3, 2010
Last updated: January 26, 2016
Last verified: January 2016
  Purpose
The study's objective is to measure changes in human visual cortex organization that may arise as a result of injury to the visual pathways. Subjects with retinal or cortical injury will be studied and compared to appropriate controls. Functional magnetic resonance imaging methods are used to monitor cortical topography in time. The main aims of the study are to determine: 1) what are the patterns of cortical reorganization that are seen spontaneously after injury, and 2) whether rehabilitative training can promote adaptive reorganization enhancing recovery.

Condition
Stroke
Blindness
Vision

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Functional Neuroimaging of Cortical Plasticity in the Human Visual System

Further study details as provided by Baylor College of Medicine:

Estimated Enrollment: 200
Study Start Date: January 2009
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2017 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with lesions of the visual pathway (cortical or retinal)
Criteria

Inclusion Criteria:

  • Stable lesion of the visual pathways resulting in a visual field scotoma.

Exclusion Criteria:

  • Inability to undergo magnetic resonance imaging,
  • Inability to comply with basic instructions,
  • Inability to perform the behavioral tasks required,
  • Patients with chronic progressive neurological or psychiatric disorders,
  • Patients that are pregnant, or breast feeding.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01062672

Contacts
Contact: Stelios M Smirnakis, MD, PhD 713-798-3972 ssmirnakis@cns.bcm.edu

Locations
United States, Texas
Baylor College of Medicine Recruiting
Houston, Texas, United States, 77030
Contact: Stelios M Smirnakis, MD, PhD    713-798-3972    ssmirnakis@cns.bcm.edu   
Principal Investigator: Stelios M Smirnakis, MD, PhD         
Germany
Max Planck Institute for Biological Cybernetics Recruiting
Tuebingen, Germany
Contact: Stelios M Smirnakis, MD, PhD    713-798-3972    ssmirnakis@cns.bcm.edu   
Contact: Elke Krapp    ++4970712980726    elke.krapp@med.uni-tuebingen.de   
Principal Investigator: Ulrich Schiefer, MD         
Sponsors and Collaborators
Baylor College of Medicine
Brigham and Women's Hospital, Harvard University
  More Information

Responsible Party: Stelios Smirnakis, Assistant Professor, Baylor College of Medicine
ClinicalTrials.gov Identifier: NCT01062672     History of Changes
Other Study ID Numbers: H--22516 
Study First Received: February 3, 2010
Last Updated: January 26, 2016
Health Authority: United States: Institutional Review Board
Germany: Federal Institute for Drugs and Medical Devices

Keywords provided by Baylor College of Medicine:
plasticity
reorganization
cortical
fMRI
rehabilitation

Additional relevant MeSH terms:
Blindness
Vision Disorders
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Eye Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on August 23, 2016