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Functional Neuroimaging of Cortical Plasticity in the Human Visual System

This study is currently recruiting participants.
Verified January 2016 by Stelios Smirnakis, Baylor College of Medicine
Sponsor:
ClinicalTrials.gov Identifier:
NCT01062672
First Posted: February 4, 2010
Last Update Posted: January 27, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborator:
Brigham and Women's Hospital
Information provided by (Responsible Party):
Stelios Smirnakis, Baylor College of Medicine
  Purpose
The study's objective is to measure changes in human visual cortex organization that may arise as a result of injury to the visual pathways. Subjects with retinal or cortical injury will be studied and compared to appropriate controls. Functional magnetic resonance imaging methods are used to monitor cortical topography in time. The main aims of the study are to determine: 1) what are the patterns of cortical reorganization that are seen spontaneously after injury, and 2) whether rehabilitative training can promote adaptive reorganization enhancing recovery.

Condition
Stroke Blindness Vision

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Functional Neuroimaging of Cortical Plasticity in the Human Visual System

Further study details as provided by Stelios Smirnakis, Baylor College of Medicine:

Estimated Enrollment: 200
Study Start Date: January 2009
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2017 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with lesions of the visual pathway (cortical or retinal)
Criteria

Inclusion Criteria:

  • Stable lesion of the visual pathways resulting in a visual field scotoma.

Exclusion Criteria:

  • Inability to undergo magnetic resonance imaging,
  • Inability to comply with basic instructions,
  • Inability to perform the behavioral tasks required,
  • Patients with chronic progressive neurological or psychiatric disorders,
  • Patients that are pregnant, or breast feeding.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01062672


Contacts
Contact: Stelios M Smirnakis, MD, PhD 713-798-3972 ssmirnakis@cns.bcm.edu

Locations
United States, Texas
Baylor College of Medicine Recruiting
Houston, Texas, United States, 77030
Contact: Stelios M Smirnakis, MD, PhD    713-798-3972    ssmirnakis@cns.bcm.edu   
Principal Investigator: Stelios M Smirnakis, MD, PhD         
Germany
Max Planck Institute for Biological Cybernetics Recruiting
Tuebingen, Germany
Contact: Stelios M Smirnakis, MD, PhD    713-798-3972    ssmirnakis@cns.bcm.edu   
Contact: Elke Krapp    ++4970712980726    elke.krapp@med.uni-tuebingen.de   
Principal Investigator: Ulrich Schiefer, MD         
Sponsors and Collaborators
Baylor College of Medicine
Brigham and Women's Hospital
  More Information

Responsible Party: Stelios Smirnakis, Assistant Professor, Baylor College of Medicine
ClinicalTrials.gov Identifier: NCT01062672     History of Changes
Other Study ID Numbers: H--22516
First Submitted: February 3, 2010
First Posted: February 4, 2010
Last Update Posted: January 27, 2016
Last Verified: January 2016

Keywords provided by Stelios Smirnakis, Baylor College of Medicine:
plasticity
reorganization
cortical
fMRI
rehabilitation

Additional relevant MeSH terms:
Blindness
Vision Disorders
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Eye Diseases
Signs and Symptoms