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Peripheral Metabolic Effects of Somatostatin

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ClinicalTrials.gov Identifier: NCT01062529
Recruitment Status : Completed
First Posted : February 4, 2010
Last Update Posted : January 21, 2013
The Ministry of Science, Technology and Innovation, Denmark
Information provided by (Responsible Party):
University of Aarhus

Brief Summary:
The aim of this study is to investigate peripheral effects of Somatostatin on glucose metabolism and growth hormone (GH) signalling in healthy men. Eight subjects will be enrolled. The hypothesis is that Somatostatin infusion reverses insulin resistance caused by GH.

Condition or disease Intervention/treatment Phase
Acromegaly Growth Hormone Deficiency Diabetes Drug: Somatostatin Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 8 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Peripheral Metabolic Effects of Intra Arterial Somatostatin Infusion in Healthy Controls
Study Start Date : October 2009
Actual Primary Completion Date : February 2010
Actual Study Completion Date : February 2010

Arm Intervention/treatment
Experimental: somatostatin Drug: Somatostatin
4 h of 150 microgram infusion

Primary Outcome Measures :
  1. Plasma levels of glucose [ Time Frame: 3 months ]

Secondary Outcome Measures :
  1. GH signalling [ Time Frame: one year ]
  2. Serum levels of free fatty acids (FFA) [ Time Frame: one year ]

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • BMI < 27 kg/m2
  • Written informed consent
  • Healthy

Exclusion Criteria:

  • Any disease
  • Any use of medications
  • Present or previous malignancy
  • Alcohol dependency
  • Allergy to trial medication

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01062529

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Medical department M
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
The Ministry of Science, Technology and Innovation, Denmark
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Principal Investigator: Jens Otto L Jørgensen, Professor
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Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT01062529    
Other Study ID Numbers: M-2008005
First Posted: February 4, 2010    Key Record Dates
Last Update Posted: January 21, 2013
Last Verified: January 2013
Keywords provided by University of Aarhus:
GH signalling
insulin resistance
Additional relevant MeSH terms:
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Bone Diseases, Endocrine
Bone Diseases
Musculoskeletal Diseases
Pituitary Diseases
Hypothalamic Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Endocrine System Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs