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Malaria Survey in Mbarara District, Uganda 2010

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01062386
Recruitment Status : Completed
First Posted : February 4, 2010
Last Update Posted : August 12, 2011
Medecins Sans Frontieres, Netherlands
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Brief Summary:

Malaria is one of the major public health problems in Sub-Saharan Africa. In response to this threat, Roll Back Malaria (RBM) has rolled back a strategy using ACT as first line therapy for malaria episode, a wide distribution of Insecticide Treated Bednet (ITN), intermittent presumptive treatment of pregnant women and indoor residual spraying. Recent epidemiological observations suggested a decline in malaria prevalence in some countries but further evidences are still needed to confirm this evolution. The RBM strategy requires the use of reliable rapid diagnostic test (RDT) for which an operational assessment is necessary. Lastly, home-based management of malaria is also an important compound of this strategy. However, a better understanding of the actual use of antimalarial drugs, of the use of bednet and of the barrier to the use of health care is important to implement good quality strategies for malaria control.

This study is a cross-sectional community based survey made of two rounds (one in January 2010 and the second in June 2010). The general objective is to measure the prevalence of infection with Plasmodium falciparum at two periods of the year (at the moment of lowest and highest transmission based on the seasonal rainfalls) and to compare it with the prevalence estimated in 2004 after the rainy season for the same area. Specific objective are the estimation of the prevalence by age stratum, the analysis of the geographical distribution of the infection, the description of the parasitological characteristics, the assessment of three RDT, the description and the analysis of the prevention and care seek behaviours related to malaria.

The study area is the great Mbarara district located in south-west of Uganda. A three-stage cluster sampling method will be used. Spatial information will be collected with global positioning system and imported to Geographical Information System. Behaviour information will be collected through face to face interview.

Condition or disease

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Study Type : Observational
Actual Enrollment : 2320 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: The Epidemiology of Malaria Among Children Under Five in Mbarara District, Uganda - A Cross-sectional Population-based Survey 2010
Study Start Date : January 2010
Actual Primary Completion Date : February 2010
Actual Study Completion Date : July 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Malaria

Primary Outcome Measures :
  1. Proportion of malaria infections in children under 5 years of age [ Time Frame: January-February 2010 ]

Secondary Outcome Measures :
  1. Proportion of families with knowledge, attitude and practice regarding malaria prevention [ Time Frame: January-February 2010 ]

Biospecimen Retention:   Samples With DNA

Blood sample for:

Malaria rapid diagnostic test, Malaria Blood smear, Malaria PCR, Anopheles mosquitoes anti-saliva antibodies

Information from the National Library of Medicine

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Ages Eligible for Study:   1 Month to 59 Months   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Children living in Great Mbarara district

Inclusion Criteria:

  • Males and females
  • Ages 1 month to 59 months

Exclusion Criteria:

  • None

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01062386

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Greater Mbarara district
Mbarara, Uganda
Sponsors and Collaborators
Medecins Sans Frontieres, Netherlands
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Principal Investigator: Carolyn Nabasumba Epicentre

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Responsible Party: Carolyn Nabasumba, Epicentre Identifier: NCT01062386     History of Changes
Other Study ID Numbers: Epicentre/Mba/2010/MalPrev
First Posted: February 4, 2010    Key Record Dates
Last Update Posted: August 12, 2011
Last Verified: August 2011

Keywords provided by Epicentre:

Additional relevant MeSH terms:
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Protozoan Infections
Parasitic Diseases