Handgrip Exercise for Arteriovenous Fistula Maturation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01061008
Recruitment Status : Completed
First Posted : February 2, 2010
Results First Posted : July 15, 2014
Last Update Posted : July 15, 2014
Betsi Cadwaladr University Health Board
Information provided by (Responsible Party):
Bangor University

Brief Summary:
The purpose of this study is to investigate whether post operative progressive forearm exercise is effective in improving arteriovenous fistula maturation in chronic kidney disease patients.

Condition or disease Intervention/treatment Phase
Chronic Kidney Disease Other: Post operative progressive handgrip exercise Other: Treatment as usual Not Applicable

Detailed Description:
The arteriovenous fistula is considered to be the gold standard form of access for haemodialysis patients, however only 37% of haemodialysis patients have this form of access. A possible explanation for this could be the high fistula failure rate due to the lack of maturation. Therefore interventions aimed at enhancing fistula maturation are warranted. One such intervention could be forearm exercise, however this recommendation is not evidence based. Therefore, the purpose of this study is to investigate whether a program of post operative progressive hand grip exercise can improve fistula maturation.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 31 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effects of Progressive Handgrip Exercise Training on Arteriovenous Fistula Maturation in Chronic Kidney Disease
Study Start Date : January 2008
Actual Primary Completion Date : January 2012
Actual Study Completion Date : January 2012

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Handgrip exercise
Handgrip exercise - patients allocated to this intervention will carry out an eight week post operative progressive handgrip exercise training program
Other: Post operative progressive handgrip exercise
As soon as possible post operation the patient will commence an eight week progressive handgrip training intervention

Active Comparator: Treatment as usual Other: Treatment as usual
Continue routine care, with removal of exercise information given to patients(if anye.g. do not give out squeeze balls)

Primary Outcome Measures :
  1. Venous Diameter. [ Time Frame: 3 months ]
    Measurements were made using duplex ultrasonagraphy. Measurements were made at predetermined distances 5 to 10 cm proximal to the anastomosis (dependent on wound dressings and turbulent flow around the anastomosis). The scanning position for each patient was traced using transparent sheets which allowed analogous measurement positions for all scans. Cross sectional vascular diameter measurements were made using conventional grey scale B Mode imaging. Diameters were measured from the inner edges of the vascular wall (Wiese & Nonnast-Daniel, 2004).

Secondary Outcome Measures :
  1. Maximum Handgrip Strength [ Time Frame: 3 months ]
  2. Handgrip Endurance [ Time Frame: 3 months ]
  3. Forearm Muscle Cross Sectional Area [ Time Frame: 3 months ]

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Stage 4-5 chronic kidney disease, attending for arteriovenous fistula creation in forearm

Exclusion Criteria:

  • Are under the age of 18years;
  • Not able to exercise forearm safely (as decided by the patients consultant)
  • Have any other uncontrolled medical condition
  • Unable to withstand transiently raised systolic blood pressure by 35 mmHg and diastolic by 25 mmHg
  • Or are unable to give consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01061008

United Kingdom
Renal unit, Ysbyty Gwynedd, North West Wales NHS Trust
Bangor, Gwynedd, United Kingdom, LL57 2PW
Sponsors and Collaborators
Bangor University
Betsi Cadwaladr University Health Board

Responsible Party: Bangor University Identifier: NCT01061008     History of Changes
Other Study ID Numbers: REC No : 07/WNo01/4
Macdonald 07/4 ( Other Identifier: R & D Reference No )
First Posted: February 2, 2010    Key Record Dates
Results First Posted: July 15, 2014
Last Update Posted: July 15, 2014
Last Verified: June 2014

Keywords provided by Bangor University:
Exercise; arteriovenous fistula; chronic kidney disease

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Arteriovenous Fistula
Urologic Diseases
Renal Insufficiency
Pathological Conditions, Anatomical
Arteriovenous Malformations
Vascular Malformations
Cardiovascular Abnormalities
Cardiovascular Diseases
Vascular Fistula
Vascular Diseases
Congenital Abnormalities