The Genetics of Chiari Type I Malformation
Duke University Medical Center is investigating the hereditary basis of Chiari type I malformations with or without syringomyelia (CM1/S). Our research is aimed at learning if CM1/S is indeed caused by factors inherited through the family and, if so, which genes are involved.
Chiari Type I Malformation
|Study Design:||Observational Model: Family-Based
Time Perspective: Cross-Sectional
|Official Title:||The Genetics of Chiari Type I Malformation (CMI) With or Without Syringomyelia|
- Genetic factors contributing to Chiari Type I malformation [ Time Frame: end of study ] [ Designated as safety issue: No ]This study aims to identify genetic factors that contribute to or cause Chiari Type I malformation.
Biospecimen Retention: Samples With DNA
Whole blood, serum, DNA
|Study Start Date:||June 2009|
|Estimated Study Completion Date:||August 2016|
|Estimated Primary Completion Date:||August 2016 (Final data collection date for primary outcome measure)|
Duke University Medical Center is actively recruiting families who have TWO OR MORE family members with Chiari Type I Malformations, with or without syringomyelia. These family members must be related to each other by blood, and BOTH must be willing to participate.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01060800
|United States, North Carolina|
|Duke University Medical Center|
|Durham, North Carolina, United States, 27710|
|Principal Investigator:||Allison Ashley-Koch, PhD||Duke University|