ClinicalTrials.gov
ClinicalTrials.gov Menu

The Genetics of Chiari Type I Malformation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01060800
Recruitment Status : Active, not recruiting
First Posted : February 2, 2010
Last Update Posted : April 18, 2018
Sponsor:
Information provided by (Responsible Party):
Duke University

Brief Summary:
Duke University Medical Center is investigating the hereditary basis of Chiari type I malformations with or without syringomyelia (CM1/S). Our research is aimed at learning if CM1/S is indeed caused by factors inherited through the family and, if so, which genes are involved.

Condition or disease
Chiari Type I Malformation

Study Type : Observational
Estimated Enrollment : 2000 participants
Observational Model: Family-Based
Time Perspective: Cross-Sectional
Official Title: The Genetics of Chiari Type I Malformation (CMI) With or Without Syringomyelia
Study Start Date : June 2009
Estimated Primary Completion Date : August 2025
Estimated Study Completion Date : August 2025

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Syringomyelia
U.S. FDA Resources




Primary Outcome Measures :
  1. Genetic factors contributing to Chiari Type I malformation [ Time Frame: end of study ]
    This study aims to identify genetic factors that contribute to or cause Chiari Type I malformation.


Biospecimen Retention:   Samples With DNA
Whole blood, serum, DNA


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study is not currently enrolling new participants.
Criteria
The study is not currently enrolling new participants.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01060800


Locations
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
Sponsors and Collaborators
Duke University
Investigators
Principal Investigator: Allison Ashley-Koch, PhD Duke University

Additional Information:
Responsible Party: Duke University
ClinicalTrials.gov Identifier: NCT01060800     History of Changes
Other Study ID Numbers: Pro00011231
First Posted: February 2, 2010    Key Record Dates
Last Update Posted: April 18, 2018
Last Verified: April 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Duke University:
Chiari
Chiari Type I
Chiari Type I Malformation
Familial Chiari

Additional relevant MeSH terms:
Congenital Abnormalities
Arnold-Chiari Malformation
Neural Tube Defects
Nervous System Malformations
Nervous System Diseases