A Controlled Trial of Extended Brief Interventions in Alcohol Dependent Patients (ADPAC)
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|ClinicalTrials.gov Identifier: NCT01060397|
Recruitment Status : Completed
First Posted : February 2, 2010
Last Update Posted : November 26, 2014
Heavy alcohol consumption leads to various health problems and is now recognised to be an important public health problem. This is evidenced by the huge media attention recently focused on the use and misuse of alcohol, particularly by younger patients. At least 1 in 20 of the population in the UK are physically and psychologically dependent on alcohol. This not only has consequences for the physical and psychological well-being of these patients, but has adverse consequences for their family, work life and society in general. Current treatments are mostly delivered in specialist units, which are few in number meaning that few patients get access to these services. This leads to a vicious cycle which results in multiple hospital admissions, ineffective treatments and continual drinking. It is therefore vital the investigators develop alternative effective treatments for these patients which can interrupt this vicious cycle.
In patients who drink heavily, but are not yet alcohol-dependent, a treatment called brief intervention can help reduce overall alcohol consumption, and improve health and wellbeing. However, whether a similar intervention can help alcohol-dependent patients has not yet been established.
In this study, the investigators aim to identify, treat and support alcohol-dependent individuals. Using an enhanced form of BI (termed extended brief intervention, EBI) as the basis of clinical care, the investigators will undertake a randomised trial comparing EBI with usual clinical care. The investigators will use various clinical and behavioural measures to assess the effectiveness of this treatment. The investigators will also be asking patients how they felt, and what they think of their treatment and the professionals delivering that treatment. If EBI is shown to be effective and is not too costly, it could provide a national framework for treatment of alcohol-dependent patients. This could potentially improve both the opportunities to access treatment and the choice of treatments available to patients.
The investigators hypothesis is that Extended Brief Interventions (EBI) delivered to alcohol-dependent patients in a hospital setting by an Alcohol Specialist Nurse (ASN) will be effective in reducing overall alcohol consumption and improving the standard measures of alcohol dependence.
|Condition or disease||Intervention/treatment|
|Alcohol Dependence||Behavioral: Extended Brief Intervention Behavioral: Control|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||267 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||A Randomized Controlled Trial of Extended Brief Interventions for Alcohol-dependent Patients in an Acute Care Setting|
|Study Start Date :||November 2009|
|Primary Completion Date :||July 2011|
|Study Completion Date :||November 2013|
Experimental: Extended Brief Intervention
FRAMES motivational interviewing approach
Behavioral: Extended Brief Intervention
Frames motivational interviewing approach
- Alcohol Use Disorders Identification Test (AUDIT) [ Time Frame: Baseline, twelve weeks and six months ]
- Measure of Dependence (Leeds Dependency Questionnaire) [ Time Frame: baseline, 12 weeks and 6 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01060397
|Southport and Ormskirk NHS Trust|
|Southport, England, United Kingdom, L39 2AZ|
|Study Chair:||Munir Pirmohamed, PhD FRCP||The University of Liverpool|