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Cerebral Antibiotics Distribution After Acute Brain Injury

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01059890
First Posted: February 1, 2010
Last Update Posted: October 11, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Poitiers University Hospital
  Purpose
The aim of the study is to explore the distribution of antibiotics in the brain after an acute brain injury because brain infections treatment is still an health care problem.

Condition Intervention Phase
Bacterial Infection Brain Injury Drug: cefotaxime Drug: Metronidazole Drug: Ciprofloxacin Drug: Fosfocine Phase 1

Study Type: Interventional

Further study details as provided by Poitiers University Hospital:

Enrollment: 18
Study Start Date: September 2009
Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cefotaxime Drug: cefotaxime
Experimental: Metrodinazole Drug: Metronidazole
Experimental: Ciprofloxacine Drug: Ciprofloxacin
Experimental: Fosfocine Drug: Fosfocine

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Acute brain injury
  • Patient who receive an antibiotic for an infection or prophylaxy
  • Glasgow coma score < 8

Exclusion Criteria:

  • Age < 18 years old
  • Pregnant woman
  • HCV, HIV, HBV infection
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01059890


Locations
France
Poitiers University Hospital - 2 rue de la Milétrie - Réanimation chirugicale
Poitiers, France, 86021
Sponsors and Collaborators
Poitiers University Hospital
  More Information

ClinicalTrials.gov Identifier: NCT01059890     History of Changes
Other Study ID Numbers: A-BRAIN
First Submitted: January 29, 2010
First Posted: February 1, 2010
Last Update Posted: October 11, 2016
Last Verified: October 2016

Additional relevant MeSH terms:
Brain Injuries
Bacterial Infections
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Craniocerebral Trauma
Trauma, Nervous System
Wounds and Injuries
Metronidazole
Ciprofloxacin
Cefotaxime
Cefoxitin
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents
Anti-Bacterial Agents
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 Enzyme Inhibitors