Cerebral Antibiotics Distribution After Acute Brain Injury

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01059890
Recruitment Status : Completed
First Posted : February 1, 2010
Last Update Posted : October 11, 2016
Information provided by:
Poitiers University Hospital

Brief Summary:
The aim of the study is to explore the distribution of antibiotics in the brain after an acute brain injury because brain infections treatment is still an health care problem.

Condition or disease Intervention/treatment Phase
Bacterial Infection Brain Injury Drug: cefotaxime Drug: Metronidazole Drug: Ciprofloxacin Drug: Fosfocine Phase 1

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 18 participants
Study Start Date : September 2009
Actual Primary Completion Date : June 2013

Arm Intervention/treatment
Experimental: Cefotaxime Drug: cefotaxime
Experimental: Metrodinazole Drug: Metronidazole
Experimental: Ciprofloxacine Drug: Ciprofloxacin
Experimental: Fosfocine Drug: Fosfocine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Acute brain injury
  • Patient who receive an antibiotic for an infection or prophylaxy
  • Glasgow coma score < 8

Exclusion Criteria:

  • Age < 18 years old
  • Pregnant woman
  • HCV, HIV, HBV infection

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01059890

Poitiers University Hospital - 2 rue de la Milétrie - Réanimation chirugicale
Poitiers, France, 86021
Sponsors and Collaborators
Poitiers University Hospital Identifier: NCT01059890     History of Changes
Other Study ID Numbers: A-BRAIN
First Posted: February 1, 2010    Key Record Dates
Last Update Posted: October 11, 2016
Last Verified: October 2016

Additional relevant MeSH terms:
Brain Injuries
Bacterial Infections
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Craniocerebral Trauma
Trauma, Nervous System
Wounds and Injuries
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents
Anti-Bacterial Agents
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 Enzyme Inhibitors