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Cerebral Antibiotics Distribution After Acute Brain Injury

This study has been completed.
Information provided by:
Poitiers University Hospital Identifier:
First received: January 29, 2010
Last updated: October 10, 2016
Last verified: October 2016
The aim of the study is to explore the distribution of antibiotics in the brain after an acute brain injury because brain infections treatment is still an health care problem.

Condition Intervention Phase
Bacterial Infection
Brain Injury
Drug: cefotaxime
Drug: Metronidazole
Drug: Ciprofloxacin
Drug: Fosfocine
Phase 1

Study Type: Interventional

Resource links provided by NLM:

Further study details as provided by Poitiers University Hospital:

Enrollment: 18
Study Start Date: September 2009
Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cefotaxime Drug: cefotaxime
Experimental: Metrodinazole Drug: Metronidazole
Experimental: Ciprofloxacine Drug: Ciprofloxacin
Experimental: Fosfocine Drug: Fosfocine


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Acute brain injury
  • Patient who receive an antibiotic for an infection or prophylaxy
  • Glasgow coma score < 8

Exclusion Criteria:

  • Age < 18 years old
  • Pregnant woman
  • HCV, HIV, HBV infection
  Contacts and Locations
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Please refer to this study by its identifier: NCT01059890

Poitiers University Hospital - 2 rue de la Milétrie - Réanimation chirugicale
Poitiers, France, 86021
Sponsors and Collaborators
Poitiers University Hospital
  More Information Identifier: NCT01059890     History of Changes
Other Study ID Numbers: A-BRAIN 
Study First Received: January 29, 2010
Last Updated: October 10, 2016
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Additional relevant MeSH terms:
Brain Injuries
Bacterial Infections
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Craniocerebral Trauma
Trauma, Nervous System
Wounds and Injuries
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents
Anti-Bacterial Agents
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 Enzyme Inhibitors processed this record on October 21, 2016