Exome Sequencing in Autistic Spectrum Disorder
- Research into the genetic causes of autism spectrum disorder (ASD) involves studies of the DNA of children with autism. New DNA sequencing technology allows researchers to study specific genes in search of genetic changes that may cause or contribute to ASD. Individuals who donated DNA to the Autism Genetic Resource Exchange may benefit from further study of their DNA samples with more advanced DNA sequencing technology.
- The role of cholesterol in individuals with ASD is currently under investigation. Research has suggested that abnormal cholesterol levels in children with autism may be related to genetic mutations or changes in how cholesterol is regulated in the body.
- To study existing blood samples of children with autism spectrum disorders to evaluate the relationship between genetic traits and cholesterol function.
- Children with ASD who donated blood samples to the Autism Genetic Resource Exchange.
- Parents/guardians of minor children with ASD will provide consent for further research to be performed on existing DNA samples in the Autism Genetic Research Exchange databank. Information from this research may be provided to the consenting parents/guardians on a case by case basis, as directed by the researchers.
|Autism Spectrum Disorder Autism Autistic Disorder|
|Study Design:||Observational Model: Cohort
Time Perspective: Other
|Official Title:||Exome Sequencing in Autistic Spectrum Disorder Patients With Altered Cholesterol Homeostasis|
|Study Start Date:||January 21, 2010|
|Estimated Study Completion Date:||May 15, 2017|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01059201
|United States, Maryland|
|Kennedy Krieger Institute|
|Baltimore, Maryland, United States, 21205|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|United States, Ohio|
|Ohio State University|
|Columbus, Ohio, United States, 43210-1240|
|Principal Investigator:||Forbes D Porter, M.D.||Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|