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High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01058161
First Posted: January 28, 2010
Last Update Posted: August 28, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Assistance Publique Hopitaux De Marseille
  Purpose
The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early detection of joint abnormalities. The additional aim of this project will be to develop a quantitative analyse of the corresponding high-resolution images.

Condition Intervention
Abnormality Inflammation Rheumatism Other: high-field MRI (3 Teslas)

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

Further study details as provided by Assistance Publique Hopitaux De Marseille:

Primary Outcome Measures:
  • can be obtained, one could expect an early detection of joint abnormalities [ Time Frame: 24 months ]

Secondary Outcome Measures:
  • will be to develop a quantitative analyse of the corresponding high-resolution images. [ Time Frame: 24 months ]

Enrollment: 34
Study Start Date: December 2009
Study Completion Date: February 2013
Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Suspects or affected by rheumatoid polyarthritis Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
stiffening spondylitis with axial and peripheral infringement Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
polyarthralgies with or without arthritis
Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
Healthy control Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
not inflammatory control
Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)
Other: high-field MRI (3 Teslas)
high-field MRI (3 Teslas)

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • gp Suspects or affected by rheumatoid polyarthritis

    1. Morning articular Stiffness of at least 15 minutes.
    2. Arthalgias or Arthritises of at least three joints(articulations), among which those of the hand.
    3. Possible rheumatoid Presence of a factor(mailman) and\or Antibody anti peptides positive citrullinés.
    4. Typical possible radiological Hurts on the standard clichés(pictures) of the reached(affected) joints(articulations).
  • gp Affected by stiffening spondylitis with axial and peripheral infringement :

    . Lumbago and steepness lumbar vertebra inflammatory. 2. Arthralgias and\or peripheral arthritises 3. Possible presence of an allèle HLA 4. Possible presence of a sacro-illite 5. Absence of the other rheumatic markers

  • gp Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis
  • gp Healthy control
  • gp Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Exclusion Criteria:

  • Claustrophobia,
  • metallic foreign bodies,
  • pacemakers The pregnant women,
  • parturients or who breast-feed are excluded from the study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01058161


Locations
France
Assistance Publique Hopitaux de Marseille
Marseille, France
Sponsors and Collaborators
Assistance Publique Hopitaux De Marseille
Investigators
Principal Investigator: sandrine guis, PU PH Assistance Publique Hopitaux De Marseille
  More Information

Responsible Party: Assistance Publique Hopitaux De Marseille
ClinicalTrials.gov Identifier: NCT01058161     History of Changes
Other Study ID Numbers: 2009-A01040-57
2009 28 ( Other Identifier: 2009 28 )
First Submitted: January 27, 2010
First Posted: January 28, 2010
Last Update Posted: August 28, 2014
Last Verified: August 2014

Keywords provided by Assistance Publique Hopitaux De Marseille:
wrist and hand cartilage abnormalities in inflammatory and chronic rheumatisms

Additional relevant MeSH terms:
Inflammation
Congenital Abnormalities
Rheumatic Diseases
Collagen Diseases
Pathologic Processes
Musculoskeletal Diseases
Connective Tissue Diseases