Ovarian Freezing Before Cancer Treatment
Women of reproductive age who will undergo cancer treatment may participate in a study to surgically remove ovarian tissue and store it, frozen, for their potential use in the future. 20% of collected tissue will be used for research.
Effects of Chemotherapy
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Ovarian Tissue Freezing Prior to Chemotherapy or Radiation Therapy: a Study by the Oncofertility Consortium|
- Follicular development in vitro [ Time Frame: 5 years ] [ Designated as safety issue: No ]Several factors, including 3-dimensional biogel scaffolds,growth factors, hormones and other culture conditions, will be investigated as they relate to successful maturation of immature follicles obtained from ovarian tissue.
Biospecimen Retention: Samples Without DNA
|Study Start Date:||February 2007|
|Estimated Study Completion Date:||January 2017|
|Estimated Primary Completion Date:||January 2017 (Final data collection date for primary outcome measure)|
Chemotherapy and radiation therapy for cancer can compromise the ability to become pregnant. Experiments in animals and humans have tried to collect, freeze and store eggs to see if they can be saved for possible later use. While studies are promising, it is still uncertain whether such approaches will ultimately prove to be useful in practice for achieving pregnancy in humans. The main purpose of this study is to see whether it is possible to remove and store ovarian tissues by freezing. It is hoped that, in the future, frozen, stored ovarian tissue can be used to achieve pregnancy. Before receiving chemotherapy or radiation therapy, subjects will have a piece of the ovaries, or one of two ovaries, removed by surgery. The tissues will be frozen by a special method in an effort to prevent the eggs from being damaged. The majority (80%) of the tissue will be stored for potential use in case the patient is unable to achieve pregnancy in the future, and part of the tissue (20%) will be used for studying how the eggs can be grown in the laboratory.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01057745
|United States, Pennsylvania|
|Penn Fertility Care, 3701 Market Street, Suite 800|
|Philadelphia, Pennsylvania, United States, 19104|
|Principal Investigator:||Clarisa Gracia, MD, MSCE||University of Pennsylvania|