Studying Gene Expression in Tissue Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at gene expression in tissue samples from young patients with acute myeloid leukemia.
|Leukemia||Genetic: RNA analysis Genetic: gene expression analysis Genetic: reverse transcriptase-polymerase chain reaction Other: laboratory biomarker analysis|
|Study Design:||Observational Model: Case-Only
Time Perspective: Retrospective
|Official Title:||EVI-1 Expression in Pediatric AML With 11q23 Abnormalities|
- Quantification of the expression of EVI1 splice variants
Biospecimen Retention: Samples With DNA
|Study Start Date:||February 2010|
|Study Completion Date:||June 2010|
|Primary Completion Date:||June 2010 (Final data collection date for primary outcome measure)|
- Examine mRNA from pediatric patients with acute myeloid leukemia with 11q23 translocations by reverse transcriptase-PCR to quantify expression of EVI1 splice variants.
OUTLINE: Cryopreserved mRNA from diagnostic samples is analyzed for gene expression by reverse transcriptase-PCR.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01057303
|Principal Investigator:||Amy Heerema-McKenney, MD||Stanford University|