Studying Gene Expression in Tissue Samples From Young Patients With Acute Myeloid Leukemia

This study has been completed.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group Identifier:
First received: January 26, 2010
Last updated: May 5, 2015
Last verified: May 2015

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at gene expression in tissue samples from young patients with acute myeloid leukemia.

Condition Intervention
Genetic: RNA analysis
Genetic: gene expression analysis
Genetic: reverse transcriptase-polymerase chain reaction
Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: EVI-1 Expression in Pediatric AML With 11q23 Abnormalities

Resource links provided by NLM:

Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • Quantification of the expression of EVI1 splice variants [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Enrollment: 20
Study Start Date: February 2010
Study Completion Date: June 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Detailed Description:


  • Examine mRNA from pediatric patients with acute myeloid leukemia with 11q23 translocations by reverse transcriptase-PCR to quantify expression of EVI1 splice variants.

OUTLINE: Cryopreserved mRNA from diagnostic samples is analyzed for gene expression by reverse transcriptase-PCR.


Ages Eligible for Study:   up to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Diagnosis of pediatric acute myeloid leukemia with 11q23 abnormalities


  • Diagnosis of pediatric acute myeloid leukemia with 11q23 abnormalities


  • Not specified


  • Not specified
  Contacts and Locations
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Please refer to this study by its identifier: NCT01057303

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Amy Heerema-McKenney, MD Stanford University
  More Information

Additional Information:
No publications provided

Responsible Party: Children's Oncology Group Identifier: NCT01057303     History of Changes
Other Study ID Numbers: AAML10B15, COG-AAML10B15, CDR0000664144, NCI-2011-02205
Study First Received: January 26, 2010
Last Updated: May 5, 2015
Health Authority: United States: Federal Government

Keywords provided by Children's Oncology Group:
childhood acute myeloid leukemia/other myeloid malignancies

Additional relevant MeSH terms:
Leukemia, Myeloid, Acute
Leukemia, Myeloid
Neoplasms by Histologic Type processed this record on November 27, 2015