Studying Gene Expression in Tissue Samples From Patients With Acute Myeloid Leukemia
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ClinicalTrials.gov Identifier: NCT01057095 |
Recruitment Status
:
Completed
First Posted
: January 27, 2010
Last Update Posted
: October 2, 2015
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RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at gene expression in tissue samples from patients with acute myeloid leukemia.
Condition or disease | Intervention/treatment |
---|---|
Leukemia | Genetic: RNA analysis Genetic: gene expression analysis Genetic: reverse transcriptase-polymerase chain reaction Other: laboratory biomarker analysis |
OBJECTIVES:
- Screen acute myeloid leukemia (AML) samples to correlate high relative expression levels of PLAGL2 and putative PLAGL2 target genes (implicated in microarray study) with potential pathogenic relevance with respect to AML development.
OUTLINE: Cryopreserved mRNA from diagnostic samples is analyzed for gene expression by reverse transcriptase-PCR.
Study Type : | Observational |
Actual Enrollment : | 20 participants |
Observational Model: | Case-Only |
Time Perspective: | Retrospective |
Official Title: | Mechanisms of PLAGL2-Induced Leukaemogenesis |
Study Start Date : | January 2010 |
Actual Primary Completion Date : | April 2010 |
Actual Study Completion Date : | April 2010 |

- Correlation of high relative expression levels of PLAGL2 and putative PLAGL2 target genes with potential pathogenic relevance
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | up to 120 Years (Child, Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
DISEASE CHARACTERISTICS:
-
Diagnosis of acute myeloid leukemia, including inv(16)(p13;q22) abnormalities
- No t(15;17)(q22;q12) or t(8;21)(q22;q22) abnormalities
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01057095
Principal Investigator: | Soheil Meshinchi, MD | Fred Hutchinson Cancer Research Center |
Responsible Party: | Children's Oncology Group |
ClinicalTrials.gov Identifier: | NCT01057095 History of Changes |
Other Study ID Numbers: |
AAML10B12 COG-AAML10B12 ( Other Identifier: Children's Oncology Group ) CDR0000664240 ( Other Identifier: Clinical Trials.gov ) NCI-2011-02208 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) ) |
First Posted: | January 27, 2010 Key Record Dates |
Last Update Posted: | October 2, 2015 |
Last Verified: | May 2015 |
Keywords provided by Children's Oncology Group:
adult acute myeloid leukemia with inv(16)(p13;q22) adult acute myeloid leukemia with 11q23 (MLL) abnormalities adult acute myeloid leukemia with del(5q) adult acute myeloid leukemia with t(16;16)(p13;q22) adult acute myeloid leukemia in remission |
recurrent adult acute myeloid leukemia untreated adult acute myeloid leukemia childhood acute myeloid leukemia in remission recurrent childhood acute myeloid leukemia untreated childhood acute myeloid leukemia and other myeloid malignancies |
Additional relevant MeSH terms:
Leukemia Leukemia, Myeloid Leukemia, Myeloid, Acute Neoplasms by Histologic Type Neoplasms |