The Impact of Pulmonary Rehabilitation in Interstitial Lung Disease (PR-ILD)

Study Description

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

The purpose of this study is to determine if pulmonary rehabilitation has any effect on breathlessness, quality of life, physical function and depression in persons with interstitial lung disease.

Condition or disease	Intervention/treatment
Interstitial Lung Disease	Other: Pulmonary rehabilitation

Study Design

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Study Type :	Observational
Actual Enrollment :	54 participants
Observational Model:	Cohort
Time Perspective:	Prospective
Official Title:	The Impact of Pulmonary Rehabilitation in Interstitial Lung Disease: A Prospective Cohort Study
Study Start Date :	February 2010
Actual Primary Completion Date :	January 2013
Actual Study Completion Date :	January 2013

Groups and Cohorts

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Group/Cohort	Intervention/treatment
Pulmonary rehabilitation	Other: Pulmonary rehabilitation; Structured education and supervised exercise program, lasting between 6 and 9 weeks.

Outcome Measures

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :

1. 6-minute walk distance [ Time Frame: Immediately following completion of pulmonary rehabilitation and 6 months following the start of pulmonary rehabilitation ]
2. Quality of life [ Time Frame: Immediately following completion of pulmonary rehabilitation and 6 months following the start of pulmonary rehabilitation ]

Secondary Outcome Measures :

1. Dyspnea [ Time Frame: Immediately following completion of pulmonary rehabilitation and 6 months following the start of pulmonary rehabilitation ]
2. Depression [ Time Frame: Immediately following completion of pulmonary rehabilitation and 6 months following the start of pulmonary rehabilitation ]

Eligibility Criteria

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	19 Years and older (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Any patient with interstitial lung disease who is referred to a participating pulmonary rehabilitation program. These patients typically have exercise limitation and dyspnea, but still possess the ability to perform some exercise.

Criteria

Inclusion Criteria:

• Adults (> 18 years old) with a diagnosis of ILD who are referred to a participating PR program

Exclusion Criteria:

• Inability to provide informed consent
• Inability to read and write English
• Any other medical condition that significantly limits the subject's ability to perform the functional measures
• Emphysema / Chronic bronchitis (FEV1 / FVC ratio < 60%)
• Previous pulmonary rehabilitation

Contacts and Locations

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Locations

United States, California
John Muir Health
Concord, California, United States, 94520
Seton Pulmonary & Cardiac Rehabilitation
Daly City, California, United States, 94015
United States, Connecticut
Yale University School of Medicine
New Haven, Connecticut, United States, 06520-8057
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Virginia
Inova Fairfax Hospital
Falls Church, Virginia, United States, 22042
Canada, British Columbia
University of British Columbia
Vancouver, British Columbia, Canada, V6Z 1Y6

Sponsors and Collaborators

University of California, San Francisco

Investigators

Principal Investigator:	Harold R Collard, MD	University of California, San Francisco
Principal Investigator:	Christopher J Ryerson, MD	University of California, San Francisco
Principal Investigator:	Chris Garvey, FNP	Seton Pulmonary & Cardiac Rehabilitation

More Information

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Ryerson CJ, Cayou C, Topp F, Hilling L, Camp PG, Wilcox PG, Khalil N, Collard HR, Garvey C. Pulmonary rehabilitation improves long-term outcomes in interstitial lung disease: a prospective cohort study. Respir Med. 2014 Jan;108(1):203-10. doi: 10.1016/j.rmed.2013.11.016. Epub 2013 Dec 4.

Responsible Party:	University of California, San Francisco
ClinicalTrials.gov Identifier:	NCT01055730 History of Changes
Other Study ID Numbers:	PR-ILD
First Posted:	January 26, 2010
Last Update Posted:	November 21, 2013
Last Verified:	November 2013

Keywords provided by University of California, San Francisco:

Pulmonary rehabilitation; Exercise therapy; Interstitial lung disease; Pulmonary fibrosis	Mobility limitation; Dyspnea; Mental health

Additional relevant MeSH terms:

Lung Diseases; Lung Diseases, Interstitial; Respiratory Tract Diseases