PET Imaging in Parkinson Disease Dementia

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 2016 by Washington University School of Medicine
Sponsor:
Information provided by (Responsible Party):
Washington University School of Medicine
ClinicalTrials.gov Identifier:
NCT01052350
First received: January 15, 2010
Last updated: January 12, 2016
Last verified: January 2016
  Purpose
The purpose of this study is to use a brain imaging method called PIB PET to determine dementia subtypes in patients with Parkinson's disease. The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.

Condition
Parkinson's Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Investigations of Dementia in Parkinson Disease

Resource links provided by NLM:


Further study details as provided by Washington University School of Medicine:

Biospecimen Retention:   Samples With DNA
whole blood

Estimated Enrollment: 320
Study Start Date: August 2006
Estimated Study Completion Date: July 2030
Estimated Primary Completion Date: July 2030 (Final data collection date for primary outcome measure)
Groups/Cohorts
Parkinson disease
individuals with Parkinson disease
healthy control
individuals without Parkinson disease

Detailed Description:
The purpose of this study is to use a brain imaging method called PIB PET to determine dementia subtypes in patients with Parkinson's disease. The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia. We will be including both PD and normal subjects in this study. This a long term study and we are considering including a total of 320 participants in this protocol.
  Eligibility

Ages Eligible for Study:   50 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Participants with and without Parkinson disease will be recruited from the Movement Disorders Center at Washington University, the St. Louis metro area, and throughout the midwest region.
Criteria

Inclusion Criteria:

  • PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.

Exclusion Criteria:

  • history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia
  • severe systemic diseases
  • inability to lie still for 90 minutes
  • metallic implants, pacemakers, or any other contraindication to MRI
  • refusal to consent to brain donation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01052350

Contacts
Contact: Barb Merz, BSN, RN 314-362-0420 merzb@npg.wustl.edu

Locations
United States, Missouri
NeuroClinical Research Unit (NCRU), Washington University School of Medicine Recruiting
St. Louis, Missouri, United States, 63110
Contact: Barb Merz, BSN, RN    314-362-0240    merzb@npg.wustl.edu   
Sponsors and Collaborators
Washington University School of Medicine
Investigators
Principal Investigator: Joel S. Perlmutter, MD Washington University School of Medicine
  More Information

Responsible Party: Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT01052350     History of Changes
Other Study ID Numbers: 06-0706 
Study First Received: January 15, 2010
Last Updated: January 12, 2016
Health Authority: United States: Institutional Review Board

Keywords provided by Washington University School of Medicine:
Parkinson disease
PET imaging
PIB
dementia

Additional relevant MeSH terms:
Parkinson Disease
Dementia
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on July 24, 2016