Impact of Nebivolol on Central Aortic Pressure

This study has been withdrawn prior to enrollment.
(Similar study already published)
Information provided by:
Creighton University Identifier:
First received: January 19, 2010
Last updated: July 29, 2011
Last verified: July 2011
A randomized, cross-over, single-blind study to compare the effects of nebivolol and metoprolol on central aortic pressure and peripheral brachial pressure in patients with stable cardiovascular disease.

Condition Intervention
Central Aortic Pressure
Drug: Nebivolol
Drug: Metoprolol

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Treatment
Official Title: Impact of Nebivolol on Central Aortic Pressure

Resource links provided by NLM:

Further study details as provided by Creighton University:

Primary Outcome Measures:
  • Stable blood pressure [ Time Frame: 6 months ] [ Designated as safety issue: No ]
    Subjects will be randomized to nebivolol or metoprolol. Their medication will be titrated so that their blood pressure is within 10% of their initial reading.

Enrollment: 0
Study Start Date: December 2009
Study Completion Date: May 2010
Primary Completion Date: May 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Nebivolol
Nebivolol therapy for 2-6 weeks depending on blood pressure readings
Drug: Nebivolol
10 mg by mouth daily for 2 weeks 20 mg by mouth daily for 2 weeks 40 mg by mouth daily for 2 weeks
Experimental: Metoprolol
Metoprolol therapy for 2-6 weeks depending on blood pressure readings
Drug: Metoprolol
dosage prescribed prior to starting on study


Ages Eligible for Study:   45 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Subjects with history of hypertension
  • Subjects who have received metoprolol for a minimum of 3 months

Exclusion Criteria:

  • Patients who have had an acute myocardial infarction, coronary revascularization or who have been hospitalized for heart failure or cardiac arrhythmia in the past 6 months
  Contacts and Locations
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Please refer to this study by its identifier: NCT01051947

United States, Nebraska
The Cardiac Center at Creighton University
Omaha, Nebraska, United States, 68131
Sponsors and Collaborators
Creighton University
Principal Investigator: Jennifer Campbell, PharmD Creighton University
  More Information

No publications provided

Responsible Party: Jennifer Campbell, PharmD, Creighton University Identifier: NCT01051947     History of Changes
Other Study ID Numbers: 08-15168 
Study First Received: January 19, 2010
Last Updated: July 29, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by Creighton University:
central aortic pressure

Additional relevant MeSH terms:
Metoprolol succinate
Adrenergic Agents
Adrenergic Antagonists
Adrenergic beta-1 Receptor Antagonists
Adrenergic beta-Antagonists
Anti-Arrhythmia Agents
Antihypertensive Agents
Autonomic Agents
Cardiovascular Agents
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses
Vasodilator Agents processed this record on February 11, 2016