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Obstructive Sleep Apnea and Venous Thromboembolism (OSAVTE)

This study has been terminated.
(Investigator left the institution)
Information provided by (Responsible Party):
University of Missouri-Columbia Identifier:
First received: January 15, 2010
Last updated: September 29, 2016
Last verified: September 2016
There is a clear link between obstructive sleep apnea (OSA) and cardiovascular disease. However, there has been no clear link between OSA and venous thromboembolism (VTE). The objective of this study is to evaluate such a link.

Obstructive Sleep Apnea Venous Thrombosis Pulmonary Embolism Venous Thromboembolism

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Patients With Obstructive Sleep Apnea (OSA), Independent of Obesity, Are at Increased Risk of Venous Thromboembolic Events (VTE)

Resource links provided by NLM:

Further study details as provided by University of Missouri-Columbia:

Primary Outcome Measures:
  • incidence of VTE for the OSA cohort [ Time Frame: 12 months ]
  • incidence of OSA for the VTE cohort [ Time Frame: 12 months ]

Secondary Outcome Measures:
  • death [ Time Frame: 12 month ]
  • bleeding [ Time Frame: 12 months ]
  • composite outcome of death, VTE , or bleeding [ Time Frame: 12 months ]

Enrollment: 85
Study Start Date: March 2009
Study Completion Date: May 2015
Primary Completion Date: May 2015 (Final data collection date for primary outcome measure)
Patients diagnosed with VTE
sleep study group -PROSPECTIVE
patients undergoing sleep study
patients with VTE , chart review
patients diagnosed with OSA

Detailed Description:


  1. retrospective chart review of all patients with VTE over 10 year period
  2. retrospective chart review of all patients with OSA over 10 year period
  3. prospective 1 year follow up of all patients diagnosed with new VTE
  4. prospective 1 year follow up of all patients undergoing sleep study

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Adult patients (>=18 years) with sleep study , OSA or VTE

Inclusion Criteria:

  • Adult patients (>= 18 years) with sleep study, OSA or VTE

Exclusion Criteria:

  • Below 18 years of age
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01051297

Sponsors and Collaborators
University of Missouri-Columbia
Principal Investigator: OUSAMA DABBAGH, MD University of Missouri-Columbia
Principal Investigator: JAMES P BOSANQUET, MD University of Missouri-Columbia
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: University of Missouri-Columbia Identifier: NCT01051297     History of Changes
Other Study ID Numbers: 1132357
Study First Received: January 15, 2010
Last Updated: September 29, 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by University of Missouri-Columbia:
Obstructive sleep apnea
venous thrombosis
pulmonary embolism
venous thromboembolism

Additional relevant MeSH terms:
Venous Thromboembolism
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Pulmonary Embolism
Venous Thrombosis
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases
Lung Diseases processed this record on September 18, 2017