Obstructive Sleep Apnea and Venous Thromboembolism (OSAVTE)

This study has been withdrawn prior to enrollment.
(Investigator left the institution)
Information provided by (Responsible Party):
University of Missouri-Columbia
ClinicalTrials.gov Identifier:
First received: January 15, 2010
Last updated: May 16, 2016
Last verified: May 2016
There is a clear link between obstructive sleep apnea (OSA) and cardiovascular disease. However, there has been no clear link between OSA and venous thromboembolism (VTE). The objective of this study is to evaluate such a link.

Obstructive Sleep Apnea
Venous Thrombosis
Pulmonary Embolism
Venous Thromboembolism

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Patients With Obstructive Sleep Apnea (OSA), Independent of Obesity, Are at Increased Risk of Venous Thromboembolic Events (VTE)

Resource links provided by NLM:

Further study details as provided by University of Missouri-Columbia:

Primary Outcome Measures:
  • incidence of VTE for the OSA cohort [ Time Frame: 12 months ] [ Designated as safety issue: No ]
  • incidence of OSA for the VTE cohort [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • death [ Time Frame: 12 month ] [ Designated as safety issue: No ]
  • bleeding [ Time Frame: 12 months ] [ Designated as safety issue: Yes ]
  • composite outcome of death, VTE , or bleeding [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Enrollment: 0
Study Start Date: March 2009
Study Completion Date: May 2015
Primary Completion Date: May 2015 (Final data collection date for primary outcome measure)
Patients diagnosed with VTE
sleep study group -PROSPECTIVE
patients undergoing sleep study
patients with VTE , chart review
patients diagnosed with OSA

Detailed Description:


  1. retrospective chart review of all patients with VTE over 10 year period
  2. retrospective chart review of all patients with OSA over 10 year period
  3. prospective 1 year follow up of all patients diagnosed with new VTE
  4. prospective 1 year follow up of all patients undergoing sleep study

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Adult patients (>=18 years) with sleep study , OSA or VTE

Inclusion Criteria:

  • Adult patients (>= 18 years) with sleep study, OSA or VTE

Exclusion Criteria:

  • Below 18 years of age
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01051297

Sponsors and Collaborators
University of Missouri-Columbia
Principal Investigator: OUSAMA DABBAGH, MD University of Missouri-Columbia
Principal Investigator: JAMES P BOSANQUET, MD University of Missouri-Columbia
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: University of Missouri-Columbia
ClinicalTrials.gov Identifier: NCT01051297     History of Changes
Other Study ID Numbers: 1132357 
Study First Received: January 15, 2010
Last Updated: May 16, 2016
Health Authority: United States: Institutional Review Board

Keywords provided by University of Missouri-Columbia:
Obstructive sleep apnea
venous thrombosis
pulmonary embolism
venous thromboembolism

Additional relevant MeSH terms:
Pulmonary Embolism
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Venous Thromboembolism
Venous Thrombosis
Cardiovascular Diseases
Embolism and Thrombosis
Lung Diseases
Nervous System Diseases
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms
Signs and Symptoms, Respiratory
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Vascular Diseases

ClinicalTrials.gov processed this record on May 26, 2016