Interaction of Apelin and Angiotensin in the Systemic Circulation
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|ClinicalTrials.gov Identifier: NCT01049646|
Recruitment Status : Completed
First Posted : January 14, 2010
Last Update Posted : August 10, 2010
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
Apelin improves that pumping ability of the heart and we wish to know if this action persists in the presence of increased levels of angiotensin II.
|Condition or disease||Intervention/treatment||Phase|
|Renin Angiotensin System||Drug: Angiotensin II Drug: Saline||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||12 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Study Start Date :||January 2010|
|Actual Primary Completion Date :||April 2010|
|Actual Study Completion Date :||April 2010|
|Active Comparator: Angiotensin II||
Drug: Angiotensin II
Infusion of a subpressor dose of angiotensin II will be give, this will be 0.5microG/min/kg. Thereafter thre ascending doses of apelin will be given, during which time cardiac output and systemic haemodynamics will be measured.
|Placebo Comparator: Saline infusion||
Infusion of saline. Thereafter three ascending doses of apelin will be given, during which time cardiac output and systemic haemodynamics will be measured.
- Cardiac output [ Time Frame: 90 mins ]
- Systemic haemodynamics [ Time Frame: 90mins ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01049646
|Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc|
|Edinburgh, United Kingdom, EH16 4SA|