Contribution of Actigraphy and Recognition Video in Apathy Assessment of Alzheimer's Disease : Experimental Research (09-PP-06)
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ClinicalTrials.gov Identifier: NCT01049555 |
Recruitment Status :
Completed
First Posted : January 14, 2010
Last Update Posted : September 30, 2015
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Neuropsychiatric symptoms form part of the clinical picture of Alzheimer's disease (AD) and other dementias. Irrespective of the severity of the disease, the most frequently encountered symptom is apathy. Apathy is increasingly diagnosed in patients with neurological and psychiatric conditions. Apathy is a disorder of motivation, defined as "the direction, intensity and persistence of goal-directed behaviour". Most of the current descriptions acknowledge this point and consider apathy in terms of a lack of goal-directed behaviour, cognition or emotion. The classical neuropsychiatric symptom assessments are subjective structured interview-based, using input from the caregiver and/or the patient. New technologies are likely to provide us with a more objective measure. An example is ambulatory actigraphy, consisting of a piezoelectric accelerometer designed to record arm movement in three dimensions.
The aim of the present study is to assess using actigraphy and video recording signal, AD patients with (n = 15) and without (n = 15) apathy and control subjects (n = 5) during an activity of daily living scenario .
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Alzheimer's Disease | Other: Actigraphy and video recording signal | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 42 participants |
Allocation: | Non-Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Official Title: | Contribution of Actigraphy and Recognition Video in Apathy Assessment of Alzheimer's Disease : Experimental Research |
Study Start Date : | September 2011 |
Actual Primary Completion Date : | September 2012 |
Actual Study Completion Date : | December 2012 |

Arm | Intervention/treatment |
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Alzheimer and apathy
Alzheimer's disease patients with apathy
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Other: Actigraphy and video recording signal
Actigraphy and video recording signal during 1 hour |
alzheimer without disease
Alzheimer's disease patients without apathy
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Other: Actigraphy and video recording signal
Actigraphy and video recording signal during 1 hour |
Case control
subject without apathy neither Alzheimer's disease
|
Other: Actigraphy and video recording signal
Actigraphy and video recording signal during 1 hour |
- assessment of motricity [ Time Frame: one time point - at the only visit of protocol ]
- video recording [ Time Frame: one time point - at the only visit of the protocol ]

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Ages Eligible for Study: | 65 Years and older (Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- male or female, > 65 years ;
- Alzheimer's disease according to the NINCDS-ADRDA criteria (McKhann,Drachman et al. 1984) ;
- Mini Mental Test Examination (MMSE) > 20 ;
- no motor anomaly according to UPDRS III (tremblements, rigidité musculaire) ;
- no depression criteria according to DSM IV-R criteria ;
- patient with a cholinergic treatment at dose stable since 3 months ;
- patient with social insurance ;
- signature of informed consent.
Exclusion Criteria:
- neuropsychologics assessment impossible due to sensorial and disrupt ;
- prescription of psychotrop treatment (hypnotic, anxiolytic, antidepressant, antipsychotic) in the week previous actigraphy recording.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01049555
France | |
Nice University Hospital | |
Nice, France, 06000 |
Principal Investigator: | Philippe ROBERT, PU-PH | Nice University Hospital |
Responsible Party: | Centre Hospitalier Universitaire de Nice |
ClinicalTrials.gov Identifier: | NCT01049555 |
Other Study ID Numbers: |
09-PP-06 |
First Posted: | January 14, 2010 Key Record Dates |
Last Update Posted: | September 30, 2015 |
Last Verified: | September 2015 |
alzheimer apathy actigraphy |
Alzheimer Disease Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases |
Tauopathies Neurodegenerative Diseases Neurocognitive Disorders Mental Disorders |