Contribution of Actigraphy and Recognition Video in Apathy Assessment of Alzheimer's Disease : Experimental Research (09-PP-06)

This study has been completed.

Sponsor:

ClinicalTrials.gov Identifier:

NCT01049555

First Posted: January 14, 2010

Last Update Posted: September 30, 2015

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Information provided by (Responsible Party):

Centre Hospitalier Universitaire de Nice

Purpose

Neuropsychiatric symptoms form part of the clinical picture of Alzheimer's disease (AD) and other dementias. Irrespective of the severity of the disease, the most frequently encountered symptom is apathy. Apathy is increasingly diagnosed in patients with neurological and psychiatric conditions. Apathy is a disorder of motivation, defined as "the direction, intensity and persistence of goal-directed behaviour". Most of the current descriptions acknowledge this point and consider apathy in terms of a lack of goal-directed behaviour, cognition or emotion. The classical neuropsychiatric symptom assessments are subjective structured interview-based, using input from the caregiver and/or the patient. New technologies are likely to provide us with a more objective measure. An example is ambulatory actigraphy, consisting of a piezoelectric accelerometer designed to record arm movement in three dimensions.

The aim of the present study is to assess using actigraphy and video recording signal, AD patients with (n = 15) and without (n = 15) apathy and control subjects (n = 5) during an activity of daily living scenario .

Condition	Intervention
Alzheimer's Disease	Other: Actigraphy and video recording signal


Study Type:	Interventional
Study Design:	Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Basic Science
Official Title:	Contribution of Actigraphy and Recognition Video in Apathy Assessment of Alzheimer's Disease : Experimental Research

Resource links provided by NLM:

Genetics Home Reference related topics: Alzheimer disease

MedlinePlus related topics: Alzheimer's Disease Health Checkup

Genetic and Rare Diseases Information Center resources: Familial Alzheimer Disease

U.S. FDA Resources

Further study details as provided by Centre Hospitalier Universitaire de Nice:

Primary Outcome Measures:

assessment of motricity [ Time Frame: one time point - at the only visit of protocol ]

Secondary Outcome Measures:

video recording [ Time Frame: one time point - at the only visit of the protocol ]


Enrollment:	42
Study Start Date:	September 2011
Study Completion Date:	December 2012
Primary Completion Date:	September 2012 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Alzheimer and apathy Alzheimer's disease patients with apathy	Other: Actigraphy and video recording signal Actigraphy and video recording signal during 1 hour
alzheimer without disease Alzheimer's disease patients without apathy	Other: Actigraphy and video recording signal Actigraphy and video recording signal during 1 hour
Case control subject without apathy neither Alzheimer's disease	Other: Actigraphy and video recording signal Actigraphy and video recording signal during 1 hour

Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:	65 Years and older (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

male or female, > 65 years ;
Alzheimer's disease according to the NINCDS-ADRDA criteria (McKhann,Drachman et al. 1984) ;
Mini Mental Test Examination (MMSE) > 20 ;
no motor anomaly according to UPDRS III (tremblements, rigidité musculaire) ;
no depression criteria according to DSM IV-R criteria ;
patient with a cholinergic treatment at dose stable since 3 months ;
patient with social insurance ;
signature of informed consent.

Exclusion Criteria:

neuropsychologics assessment impossible due to sensorial and disrupt ;
prescription of psychotrop treatment (hypnotic, anxiolytic, antidepressant, antipsychotic) in the week previous actigraphy recording.

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01049555

Locations


France
Nice University Hospital
Nice, France, 06000

Sponsors and Collaborators

Centre Hospitalier Universitaire de Nice

Investigators


Principal Investigator:	Philippe ROBERT, PU-PH	Nice University Hospital

More Information


Responsible Party:	Centre Hospitalier Universitaire de Nice
ClinicalTrials.gov Identifier:	NCT01049555 History of Changes
Other Study ID Numbers:	09-PP-06
First Submitted:	January 12, 2010
First Posted:	January 14, 2010
Last Update Posted:	September 30, 2015
Last Verified:	September 2015

Keywords provided by Centre Hospitalier Universitaire de Nice:


alzheimer apathy actigraphy

Additional relevant MeSH terms:


Alzheimer Disease Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases	Tauopathies Neurodegenerative Diseases Neurocognitive Disorders Mental Disorders

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